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In high school, Hamosh participated in the summer program at the Jackson Laboratory in Bar Harbor, Maine. At the medical genetics clinic, she was introduced to patients with inherited conditions, and to her mentor, Victor McKusick... partly to continue working with McKusick. McKusick introduced her to the Amish, the Little People of America organization, and the National Marfan Foundation. Hamosh completed the Osler Residency in Internal Medicine at Hopkins along with her Genetics fellowship.
