Zinc picolinate

Zinc picolinate
Identifiers
CAS Number	17949-65-4;
3D model (JSmol)	Interactive image;
ChemSpider	8080400;
ECHA InfoCard	100.132.913
PubChem CID	9904746;
UNII	ALO92O31SE;
CompTox Dashboard (EPA)	DTXSID60170814 ;
	InChI InChI=1S/2C6H5NO2.Zn/c28-6(9)5-3-1-2-4-7-5;/h21-4H,(H,8,9);/q;;+2/p-2 Key: NHVUUBRKFZWXRN-UHFFFAOYSA-L;
	SMILES C1=CC=NC(=C1)C(=O)[O-].C1=CC=NC(=C1)C(=O)[O-].[Zn+2];
Properties
Chemical formula	C12H12N2O6Zn
Molar mass	345.62 g·mol−1
Hazards
	GHS labelling:
Pictograms
Signal word	Warning
Hazard statements	H302, H315, H319, H335, H410
Precautionary statements	P261, P264, P270, P271, P273, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P391, P403+P233, P405, P501
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

Zinc picolinate (or ZnPic) is the zinc coordination complex derived from picolinic acid and zinc(II). It has the formula Zn(NC₅H₄CO₂)₂(H₂O)₂. The complex adopts an octahedral molecular geometry, containing two bidentate picolinate ligands (conjugate base of picolinic acid) and two aquo ligands. Additionally, two water of crystallization are present, thus the compound crystallizes with the formula Zn(NC₅H₄CO₂)₂(H₂O)₂·2H₂O.^[1] It is a colorless solid.

Related compounds

Other zinc(II) complexes of picolinic acid have been described.^[2] Isostructural with the zinc complex are M(NC₅H₄CO₂)₂(H₂O)₂·2H₂O (M = Co and Ni).^[3]

Dietary supplement

Zinc picolinate has been used as a dietary zinc supplement.^[4]^[5]^[6]

References

^ Lumme, Paavo; Lundgren, Georg; Mark, Wanda; Lundström, Hans; Borch, Gunner; Craig, J. Cymerman (1969). "The Crystal Structure of Zinc Picolinate Tetrahydrate, Zn(C₆H₄O₂N)₂(H₂O)₄". Acta Chemica Scandinavica. 23: 3011–3022. doi:10.3891/acta.chem.scand.23-3011.
^ Vargová, Zuzana; Zeleòák, Vladimı́r; Cı́Saøová, Ivana; Györyová, Katarı́na (2004). "Correlation of Thermal and Spectral Properties of Zinc(II) Complexes of Pyridinecarboxylic Acids with Their Crystal Sructures". Thermochimica Acta. 423 (1–2): 149–157. doi:10.1016/j.tca.2004.03.016.
^ Tella, Adedibu C.; Oladipo, Adetola C.; Adeyemi, Olalere G.; Oluwafemi, Oluwatobi S.; Oguntoye, Stephen O.; Alimi, Lukman O.; Ajayi, Joseph T.; Degni, Sylvestre K. (2017). "Solid State Synthesis, Spectroscopic and X-Ray Studies of Metal Complexes of 2-Picolinic Acid and Vapochromic Behavior of [Co(Pic)₂(H₂O)₂ ]·2H₂O". Solid State Sciences. 68: 1–9. doi:10.1016/j.solidstatesciences.2017.03.017.
^ Walsh CT, Sandstead HH, Prasad AS, Newberne PM, Fraker PJ (June 1994). "Zinc: Health Effects and Research Priorities for the 1990s". Environmental Health Perspectives. 102 (Suppl 2): 5–46. doi:10.1289/ehp.941025. PMC 1567081. PMID 7925188.
^ Sakai F, Yoshida S, Endo S, Tomita H (2002). "Double-Blind, Placebo-Controlled Trial of Zinc Picolinate for Taste Disorders". Acta Oto-Laryngologica. Supplementum. 122 (546): 129–33. doi:10.1080/00016480260046517. PMID 12132610. S2CID 23717414.
^ Barrie SA, Wright JV, Pizzorno JE, Kutter E, Barron PC (June 1987). "Comparative Absorption of Zinc Picolinate, Zinc Citrate and Zinc Gluconate in Humans". Agents and Actions. 21 (1–2): 223–8. doi:10.1007/BF01974946. PMID 3630857. S2CID 23567370.

[1] Lumme, Paavo; Lundgren, Georg; Mark, Wanda; Lundström, Hans; Borch, Gunner; Craig, J. Cymerman (1969). "The Crystal Structure of Zinc Picolinate Tetrahydrate, Zn(C₆H₄O₂N)₂(H₂O)₄". Acta Chemica Scandinavica. 23: 3011–3022. doi:10.3891/acta.chem.scand.23-3011.

[2] Vargová, Zuzana; Zeleòák, Vladimı́r; Cı́Saøová, Ivana; Györyová, Katarı́na (2004). "Correlation of Thermal and Spectral Properties of Zinc(II) Complexes of Pyridinecarboxylic Acids with Their Crystal Sructures". Thermochimica Acta. 423 (1–2): 149–157. doi:10.1016/j.tca.2004.03.016.

[3] Tella, Adedibu C.; Oladipo, Adetola C.; Adeyemi, Olalere G.; Oluwafemi, Oluwatobi S.; Oguntoye, Stephen O.; Alimi, Lukman O.; Ajayi, Joseph T.; Degni, Sylvestre K. (2017). "Solid State Synthesis, Spectroscopic and X-Ray Studies of Metal Complexes of 2-Picolinic Acid and Vapochromic Behavior of [Co(Pic)₂(H₂O)₂ ]·2H₂O". Solid State Sciences. 68: 1–9. doi:10.1016/j.solidstatesciences.2017.03.017.

[4] Walsh CT, Sandstead HH, Prasad AS, Newberne PM, Fraker PJ (June 1994). "Zinc: Health Effects and Research Priorities for the 1990s". Environmental Health Perspectives. 102 (Suppl 2): 5–46. doi:10.1289/ehp.941025. PMC 1567081. PMID 7925188.

[5] Sakai F, Yoshida S, Endo S, Tomita H (2002). "Double-Blind, Placebo-Controlled Trial of Zinc Picolinate for Taste Disorders". Acta Oto-Laryngologica. Supplementum. 122 (546): 129–33. doi:10.1080/00016480260046517. PMID 12132610. S2CID 23717414.

[6] Barrie SA, Wright JV, Pizzorno JE, Kutter E, Barron PC (June 1987). "Comparative Absorption of Zinc Picolinate, Zinc Citrate and Zinc Gluconate in Humans". Agents and Actions. 21 (1–2): 223–8. doi:10.1007/BF01974946. PMID 3630857. S2CID 23567370.

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