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Welcome!

Hello, Gerriet42, and welcome to Wikipedia! Thank you for your contributions. I hope you like the place and decide to stay. Here are some pages that you might find helpful:

I hope you enjoy editing here and being a Wikipedian! Please sign your messages on discussion pages using four tildes ~~~~; this will automatically insert your username and the date. If you need help, check out Wikipedia:Questions, ask me on my talk page, or ask your question and then place {{helpme}} before the question on your talk page. Again, welcome! Melchoir 02:10, 25 October 2007 (UTC)[reply]

Hi there

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We seem to be reverting each other's work, so maybe it would make sense to talk and discuss what we can agree on and agree to disagree. Benzophenone is not a component of sunscreens so I removed FEBS Lett ref from there, its irrelevant - at least in my view. More significant is the Padimate O article. I am trying to do several things with my edits, two of which sould be fairly okay with you: upgrade English, use wiki-format (links, capitalizing subheaders). The place where we seem to differ is the degree to which you want to help the reader extrapolate from the photocarcinogenicity of Micher's ketone to the conclusion that Padimate O is causing melanoma. I feel that you are speculating and over-reaching (but surely you dont see it that way!). So let's talk for a while (we can discuss it on this site, if that's okay) and see if we can iron out some consensus. These reversion cycles really set editors on edge, beyond reason. Cheers,--Smokefoot (talk) 19:54, 10 May 2008 (UTC)[reply]

Hi, It was not written that benzophenone was an ingredient in sunscreens. However it was written that derivatives of benzophenone are used as sunscreen ingredients. I would like to keep this in the article, because it is a point that had been criticized repeatedly by researchers. [1][2][3]
Are you aware, that most epidemiological studies show an increased melanoma risk for sunscreen users compared to non users? See[4][5][6][7][8]
You should read the Kerry Hanson paper. They measure the concentration of ROS inside the skin and they compare sunscreen treated with untreated skin. They see, that after the sunscreen had time to penetrate into the skin the concentration of ROS is substantially higher than in the untreated skin.[9]
About Padimate O: I think that Knowland and McKenzie say exactly what I wrote: These findings are an indication for a photocarcinogenic effect of padimate O. These findings are in agreement with those from Xu et al. They have shown that human melanocytes suffer more DNA damage from UV-illumination when in contact with padimate O then they do without this sunscreen ingredient.[10] Even at a very low concentration of 25 μmol/l the combination of padimate O with solar UV exposure can selectively damage this type of human skin cells. This concentration of the sunscreen ingredient is likely to be achieved in the skin.[10] Gerriet42 (talk) 06:09, 13 May 2008 (UTC)[reply]

thanks for the note. The thing that some of us are leery about is turning these articles into advice columns, since advice is specifically discouraged in this encyclopedia and anything verging on original research. Benzophenone is a very common building block and is, formally, a structural component of many hundreds of species, some good and some bad. While I can see your point on the wording of the padimate-O, I question the value of adding every mention of any skeletal connection between all benzophenone species and the parent molecule. The article on benzophenone would be unwieldy and the core information (what is it and what are is main properties) would be diluted out. Why not connect sunscreens to benzene too, since sunscreens are benzene derivatives? So you can see what I mean, hopefully. More later, off to work. --Smokefoot (talk)

References

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  1. ^ Damiani E. Carloni P. Biondi C. Greci L. (2000). "Increased oxidative modification of albumin when illuminated in vitro in the presence of a common sunscreen ingredient: protection by nitroxide radicals - fractionated studies". Free Radical Biology and Medicine. 28 (2): 193–201.
  2. ^ Damiani, E.; Greci, L.; Parsons, R.; Knowland (1999). "Nitroxide radicals protect DNA from damage when illuminated in vitro in the presence of dibenzoylmethane and a common sunscreen ingredient". Free Radic. Biol. Med. 26: 809–816.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  3. ^ Knowland, John; McKenzie, Edward A.; McHugh, Peter J.; Cridland, Nigel A. (1993). "Sunlight-induced mutagenicity of a common sunscreen ingredient". FEBS Letters. 324(3): 309–313.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  4. ^ Garland C, Garland F, Gorham E (1992). "Could sunscreens increase melanoma risk?". Am J Public Health. 82 (4): 614–5. PMID 1546792.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  5. ^ Westerdahl J; Ingvar C; Masback A; Olsson H (2000). "Sunscreen use and malignant melanoma". International journal of cancer. Journal international du cancer. 87: 145–50.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  6. ^ Autier P; Dore J F; Schifflers E; et al. (1995). "Melanoma and use of sunscreens: An EORTC case control study in Germany, Belgium and France". Int. J. Cancer. 61: 749–755. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link)
  7. ^ Weinstock, M. A. (1999). "Do sunscreens increase or decrease melanoma risk: An epidemiologic evaluation". Journal of Investigative Dermatology Symposium Proceedings. 4: 97–100.
  8. ^ Vainio, H., Bianchini, F. (2000). "Cancer-preventive effects of sunscreens are uncertain". Scandinavian Journal of Work Environment and Health. 26: 529–31.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  9. ^ Hanson Kerry M.; Gratton Enrico; Bardeen Christopher J. (2006). "Sunscreen enhancement of UV-induced reactive oxygen species in the skin". Free Radical Biology and Medicine. 41 (8): 1205–1212. {{cite journal}}: Cite has empty unknown parameter: |1= (help)CS1 maint: multiple names: authors list (link)
  10. ^ a b Xu, C.; Green, Adele; Parisi, Alfio; Parsons, Peter G (2001). "Photosensitization of the Sunscreen Octyl p-Dimethylaminobenzoate b UVA in Human Melanocytes but not in Keratinocytes". Photochemistry and Photobiology. 73 (6): 600–604. {{cite journal}}: Cite has empty unknown parameter: |month= (help)CS1 maint: multiple names: authors list (link)


Re: sunscreen discrepancy and sunscreen controversy

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Please consider using the move function instead; or, if the title change is controversial, consider requested moves. --slakr\ talk / 07:44, 15 May 2008 (UTC)[reply]

Apology

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You are correct. I have been overagressive in editing and have been assuming bad faith in edits such as this one. TheRedPenOfDoom (talk) 13:41, 17 May 2008 (UTC)[reply]

Sunscreen archive

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I archived the section in Sunscreen:talk that you deleted at http://en.wiki.x.io/wiki/Talk:Sunscreen/Archive_1, with the other archives. You really should put in a summary when you delete like that, and always put into an archive instead of just delete wholesale. Deleted nonsense, etc. isnt an issue, but it appears that most of that conversation was legit. PHARMBOY (TALK) 09:20, 5 September 2008 (UTC)[reply]

WikiProject Medicine/Dermatology task force

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I wanted to know if you (or any friends of yours) are interested in dermatology, and would be willing to help me with the WikiProject Medicine/Dermatology task force? Kilbad (talk) 03:00, 18 October 2008 (UTC)[reply]

ArbCom elections are now open!

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Hi,
You appear to be eligible to vote in the current Arbitration Committee election. The Arbitration Committee is the panel of editors responsible for conducting the Wikipedia arbitration process. It has the authority to enact binding solutions for disputes between editors, primarily related to serious behavioural issues that the community has been unable to resolve. This includes the ability to impose site bans, topic bans, editing restrictions, and other measures needed to maintain our editing environment. The arbitration policy describes the Committee's roles and responsibilities in greater detail. If you wish to participate, you are welcome to review the candidates' statements and submit your choices on the voting page. For the Election committee, MediaWiki message delivery (talk) 13:38, 24 November 2015 (UTC)[reply]

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