User:WindEnthusiast/sandbox

In addition to the calculated peptide scores Mascot also estimates the False Discovery Rate (FDR) by searching against a decoy database. A decoy search generates a randomized sequence of the same length for every sequence in the target database and tries to match it. The decoy sequence is generated such that it has the same average amino acid composition as the target database. This additional feature was added to comply with research publishing guidelines ^[1] ^[2].

Two images compared top and bottom. The top is a wikipedia image and the bottom one is too! How amazing..

^ Bradshaw, R. A. (31 January 2006). "Reporting Protein Identification Data: The next Generation of Guidelines". Molecular & Cellular Proteomics. 5 (5): 787–788. doi:10.1074/mcp.E600005-MCP200. PMID 16670253.{{cite journal}}: CS1 maint: unflagged free DOI (link)
^ Elias, Joshua E.; Haas, Wilhelm; Faherty, Brendan K.; Gygi, Steven P. (1 September 2005). "Comparative evaluation of mass spectrometry platforms used in large-scale proteomics investigations". Nature Methods. 2 (9): 667–675. doi:10.1038/nmeth785. PMID 16118637.

[1] Bradshaw, R. A. (31 January 2006). "Reporting Protein Identification Data: The next Generation of Guidelines". Molecular & Cellular Proteomics. 5 (5): 787–788. doi:10.1074/mcp.E600005-MCP200. PMID 16670253.{{cite journal}}: CS1 maint: unflagged free DOI (link)

[2] Elias, Joshua E.; Haas, Wilhelm; Faherty, Brendan K.; Gygi, Steven P. (1 September 2005). "Comparative evaluation of mass spectrometry platforms used in large-scale proteomics investigations". Nature Methods. 2 (9): 667–675. doi:10.1038/nmeth785. PMID 16118637.

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