User:Rvseanna2/Glycerol phosphate shuttle
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Article Draft
[edit]Lead
[edit]The glycerol-3-phosphate shuttle is a mechanism that regenerates NAD+ from NADH, a by-product of glycolysis. GPD1 is a gene that encodes proteins responsible for converting dihydroxyacetone phosphate and NADH to glycerol-3-phosphate and NAD+ for bodily metabolic processes.[1]
While the gene GPD2 is responsible for the reverse reaction.[2] Its importance in transporting reducing equivalents is secondary to the malate-aspartate shuttle.
Article body- "Function" section
[edit]The glycerol-3-phosphate shuttle allows the NADH synthesized in the cytosol by glycolysis to contribute to the oxidative phosphorylation pathway in the mitochondria to generate ATP. It has been found in animals, fungi, and plants. Furthermore on fungi, it was uncertain how glycerol-3-phosphate shuttle actually affects or conducts in poisoned fungi. A 2018 study by researchers Yongkai Shi, Huan Wang, Yuxin Yan, Huojuan Cao, Xiaohong Liu, Fucheng Lin, and Jianping Lu, shows that when glycerol-3-phosphate dehydrogenases 1 and 2 are removed from Pyricularia oryzae, it reduces its venom.[3] These enzymes aid in the glycerol-3-phosphate shuttle which is involved in fungal development. Their removal hinders the process.
References
[edit]- ^ "GPD1 glycerol-3-phosphate dehydrogenase 1 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2021-05-03.
- ^ "GPD2 glycerol-3-phosphate dehydrogenase 2 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2021-05-03.
- ^ Shi, Yongkai; Wang, Huan; Yan, Yuxin; Cao, Huijuan; Liu, Xiaohong; Lin, Fucheng; Lu, Jianping (2018). "Glycerol-3-Phosphate Shuttle Is Involved in Development and Virulence in the Rice Blast Fungus Pyricularia oryzae". Frontiers in Plant Science. 9. doi:10.3389/fpls.2018.00687. ISSN 1664-462X.
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