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User:JulesUAB/Prognosis of schizophrenia

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Below is my contribution to the Prognosis of schizophrenia article.

Treatment

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While there is no cure for schizophrenia, there are treatment options that aim to reduce symptoms and teach those affected how to manage their day to day lives. In 1952, Chlorpromazine became the first typical antipsychotic medication that would effectively reduce hallucinations and delusions by blocking dopamine receptors. Continuous drug discovery has allowed for atypical antipsychotics. Rather than being limited to only blocking dopamine receptors, atypical antipsychotics also block serotonin receptors, which allows for the elevated levels of serotonin in schizophrenics to become balanced.[1] With atypical antipsychotics, tremors are often reported as a common side effect because dopamine is involved in processing movement related neurons.[2] In addition to the antipsychotics, schizophrenics are also typically prescribed anti-tremor medications. Aside from pharmacological treatment, cognitive behavior therapy is recommended to restructure undesirable thoughts and behaviors. Shown to be the most effective treatment, cognitive behavior therapy is intended to be supplemental to antipsychotic medication.[3] Utilizing cognitive behavior therapy, schizophrenic patients may learn to replace negative thoughts and behaviors constructively, distinguish reality from hallucinations or delusions, and develop coping skills; while antipsychotics treat symptoms of psychosis. Additionally, the use of atypical antipsychotics is associated with a longer life in comparison to the absence of antipsychotics.[4]

Comorbidity

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Those affected by schizophrenia are also more inclined to suffer from numerous physiological and psychological conditions. Most notably, schizophrenic individuals experience higher rates of substance abuse and suicidality; where more than half of schizophrenics have reported suicide ideation or attempts, and nearly half suffer from substance abuse or dependence.[5] Because smoking is the most prevalent form of substance abuse among schizophrenics, they are also predisposed to suffering from a number of physical conditions associated with a high smoking frequency. The rates of smoking for schizophrenics is as high as four times that of the general population, contributing to schizophrenics increased risk of excess mortality, heart and lung diseases, and even diabetes.[4]

Article Draft

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Lead

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Article body

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References

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Instructor feedback: I don't disagree with the redundancy you found in the article, but I do not understand how we went from females having a better prognosis to males? Why did you not carry up the statement about studies being of a correlational nature? What other proposed edits do you have for this article moving forward?

  1. ^ Caccia, Silvio (2010-02). "New atypical antipsychotics for schizophrenia: iloperidone". Drug Design, Development and Therapy: 33. doi:10.2147/DDDT.S6443. ISSN 1177-8881. PMC 2846148. PMID 20368905. {{cite journal}}: Check date values in: |date= (help)CS1 maint: PMC format (link) CS1 maint: unflagged free DOI (link)
  2. ^ Drago, Antonio; Crisafulli, Concetta; Serretti, Alessandro (2011-12). "The genetics of antipsychotic induced tremors: A genome-wide pathway analysis on the STEP-BD SCP sample". American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. 156 (8): 975–986. doi:10.1002/ajmg.b.31245. {{cite journal}}: Check date values in: |date= (help)
  3. ^ Turkington, Douglas; Dudley, Robert; Warman, Debbie M.; Beck, Aaron T. (2006-04). "Cognitive-Behavioral Therapy for Schizophrenia: A Review". FOCUS. 4 (2): 223–233. doi:10.1176/foc.4.2.223. ISSN 1541-4094. {{cite journal}}: Check date values in: |date= (help)
  4. ^ a b Filipþiü, Ivona; Filipþiü, Igor. "Schizophrenia and physical comorbidity". Psychiatria Danubina. 30: 152–157.
  5. ^ Sher, Leo; Kahn, René S. (2019-07-10). "Suicide in Schizophrenia: An Educational Overview". Medicina. 55 (7): 361. doi:10.3390/medicina55070361. ISSN 1648-9144.{{cite journal}}: CS1 maint: unflagged free DOI (link)