User:Itzelhm97/Folate receptor gamma
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FOLR Family Background
[edit]The folate receptor gamma is a protein, that in humans is encoded by the FOLR3 gene.[1] It is one of three isoforms to the folate receptor.The folic acid receptors (FOLRs) are involved in up-taking folic acid.[2]
FOLR3 Family location
[edit]The FOLR multi-gene family (FOLR1, FOLR2 and FOLR3) is localized to chromosome 11q13.3–q14.1, and encodes the gene products FRα, β and γ, respectively. [3]
FOLR3 is a localized haematopoietic tissue, such as spleen and bone marrow, and is present as a secretory protein16,17. FOLR3 expresses in humans rather than mice and rats.[4]
FOLR3 function
[edit]The FOLR3 gene is polymorphic due to a nonsense mutation resulting in a truncated protein; FRγ, which can bind folic acid. FOLR3 genes each consist of 5 exons, 4 introns and 1 promoter that encodes a single transcript. [5]
Recent studies suggest FOLR3 is correlated more strongly with plasma homocysteine(Hcy) than FOLR1 and FOLR2. FOLR3 may decrease plasma Hcy compared with other FOLRs.[6] It was demonstrated that FOLR3 can metabolize both intracellular Hcy and extracellular Hcy. These results indicate that an increase in FOLR3 may effectively ameliorate Hcy in the blood and weaken Hcy-induced toxicity, even in tissues with the low level of FOLR1 and FOLR2 expression.[7]
References
[edit]- ^ "Entrez Gene: FOLR2 folate receptor 2 (fetal)".
- ^ Yoshitomi, Ren; Nakayama, Kai; Yamashita, Shuya; Kumazoe, Motofumi; Lin, Ting-An; Mei, Chen-Yi; Marugame, Yuki; Fujimura, Yoshinori; Maeda-Yamamoto, Mari; Kuriyama, Shinichi; Tachibana, Hirofumi (2020-06-24). "Plasma Homocysteine Concentration is Associated with the Expression Level of Folate Receptor 3". Scientific Reports. 10 (1): 10283. doi:10.1038/s41598-020-67288-9. ISSN 2045-2322. PMC 7314855. PMID 32581311.
{{cite journal}}: CS1 maint: PMC format (link) - ^ Kelemen, Linda E. (2006-07-15). "The role of folate receptor α in cancer development, progression and treatment: Cause, consequence or innocent bystander?". International Journal of Cancer. 119 (2): 243–250. doi:10.1002/ijc.21712. ISSN 0020-7136.
- ^ Yoshitomi, Ren; Nakayama, Kai; Yamashita, Shuya; Kumazoe, Motofumi; Lin, Ting-An; Mei, Chen-Yi; Marugame, Yuki; Fujimura, Yoshinori; Maeda-Yamamoto, Mari; Kuriyama, Shinichi; Tachibana, Hirofumi (2020-06-24). "Plasma Homocysteine Concentration is Associated with the Expression Level of Folate Receptor 3". Scientific Reports. 10 (1): 10283. doi:10.1038/s41598-020-67288-9. ISSN 2045-2322. PMC 7314855. PMID 32581311.
{{cite journal}}: CS1 maint: PMC format (link) - ^ Kelemen, Linda E. (2006-07-15). "The role of folate receptor α in cancer development, progression and treatment: Cause, consequence or innocent bystander?". International Journal of Cancer. 119 (2): 243–250. doi:10.1002/ijc.21712. ISSN 0020-7136.
- ^ Yoshitomi, Ren; Nakayama, Kai; Yamashita, Shuya; Kumazoe, Motofumi; Lin, Ting-An; Mei, Chen-Yi; Marugame, Yuki; Fujimura, Yoshinori; Maeda-Yamamoto, Mari; Kuriyama, Shinichi; Tachibana, Hirofumi (2020-06-24). "Plasma Homocysteine Concentration is Associated with the Expression Level of Folate Receptor 3". Scientific Reports. 10 (1): 10283. doi:10.1038/s41598-020-67288-9. ISSN 2045-2322. PMC 7314855. PMID 32581311.
{{cite journal}}: CS1 maint: PMC format (link) - ^ Yoshitomi, Ren; Nakayama, Kai; Yamashita, Shuya; Kumazoe, Motofumi; Lin, Ting-An; Mei, Chen-Yi; Marugame, Yuki; Fujimura, Yoshinori; Maeda-Yamamoto, Mari; Kuriyama, Shinichi; Tachibana, Hirofumi (2020-06-24). "Plasma Homocysteine Concentration is Associated with the Expression Level of Folate Receptor 3". Scientific Reports. 10 (1): 10283. doi:10.1038/s41598-020-67288-9. ISSN 2045-2322. PMC 7314855. PMID 32581311.
{{cite journal}}: CS1 maint: PMC format (link)