Template:Side effects of estrogen plus high- versus low-dose cyproterone acetate in women
| Side effect | High-dose[a] (n = 602) (%) |
Low-dose[b] (n = 226) (%) | |
|---|---|---|---|
| Fatigue | 22.0 | 13.0 | |
| Weight gain (>2 kg or >4.4 lbs) | 18.5 | 5.5 | |
| Decreased libido | 10.0 | 6.0 | |
| Breast discomfort | 9.2 | 15.0 | |
| Nausea | 9.0 | 3.9 | |
| Headaches | 7.3 | 10.4 | |
| Depression | 5.1 | 2.0 | |
| Irregular uterine bleeding | 3.5 | 7.2 | |
| Sleep disturbance | 3.5 | – | |
| Thrombophlebitis | 1.0 | 3.0 | |
| Chloasma | 0.9 | – | |
| Constipation | 0.5 | – | |
| Thrombosis | 0.15 | 0.9 | |
| Heavy legs or cramps | – | 4.6 | |
Footnotes:
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References
- ^ Hammerstein, J. (1990). "Antiandrogens: Clinical Aspects". Hair and Hair Diseases. pp. 827–886. doi:10.1007/978-3-642-74612-3_35.
- ^ Hammerstein J, Moltz L, Schwartz U (July 1983). "Antiandrogens in the treatment of acne and hirsutism". J. Steroid Biochem. 19 (1B): 591–7. doi:10.1016/0022-4731(83)90223-6. PMID 6224974.
- ^ Hammerstein J, Meckies J, Leo-Rossberg I, Moltz L, Zielske F (June 1975). "Use of cyproterone acetate (CPA) in the treatment of acne, hirsutism and virilism". J. Steroid Biochem. 6 (6): 827–36. doi:10.1016/0022-4731(75)90311-8. PMID 126335.
- ^ Moltz, L.; Meckies, J.; Hammerstein, J. (1979). "Die kontrazeptive Betreuung androgenisierter Frauen mit einem niedrig dosierten cyproteronacetathaltigen Einphasenpräparat" [The contraceptive care of androgenized women with a low-dose cyproterone acetate-containing single-phase preparation]. Deutsche Medizinische Wochenschrift. 104 (39): 1376–1382. doi:10.1055/s-0028-1129104. ISSN 0012-0472.
- ^ Moltz L; Schwartz U; Hammerstein J (1 September 1982). "Management of cutaneous virilism with cyproterone acetate". In Jeffcoate SL (ed.). Androgens and Antiandrogen Therapy (Current Topics in Reproductive Endocrinology). Chichester, England; New York: Wiley-Blackwell. p. 113. ISBN 978-0471101543.