Talk:Nuclear pore complex

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Untitled

Accroding to image from article there is nuclear basket (?= nucleoplasmic basket) and distal ring. --Snek01 09:07, 21 April 2006 (UTC)[reply]

Thanks, more accurate now! Adenosine | Talk 03:08, 22 September 2006 (UTC)[reply]

Size of the pore

There are uncited numbers that specify the size of the NPC:

The entire pore complex has a diameter of about 120 nm, the diameter of the opening is about 50 nm wide and its "depth" is about 200 nm.

I am sure these numbers vary greatly by organizm, but I found a paper on the frog oocytes sizes:

Hinshaw JE, Carragher BO, Milligan RA. "Architecture and design of the nuclear pore complex." Cell. 1992 Jun 26;69(7):1133-41. PMID 1617726

where they state:

"Stain penetration between the center and outer regions in each spoke, at a radius of ~465 A, correlates closely with the known radial position of the membrane (r = ~450 A) (Unwin and Milligan, 1982)." [10 A = 1 nm]

and also:

"The rings have weak 8-fold symmetry and consist of a ~150 A-wide circle of mass centered at a radius of about ~450 A." [10 A = 1 nm]

so these numbers are very different than the ones in the wiki article.

--vossman 19:33, 4 April 2007 (UTC)[reply]

Oops, these number correlate pretty well. I forgot to do the radius to diameter conversion.

--vossman 20:04, 4 April 2007 (UTC)[reply]

But these are nanometers, why does the article say micrometers? That's the size scale of living cells! the diagram itself shows 120 nm opening... 132.77.4.129 (talk) 21:19, 19 April 2009 (UTC)[reply]

Nuclear Pore directionality

Looking at the nuclear pore, it seems like the dangling cage at the bottom is a one-way gate: it is more likely for proteins to pass down than up. Could it be that the 2000 nuclear pores are oriented roughly half up and half down, allowing one-way traffic in and out of the nucleus? Has any research been done on this? —The preceding unsigned comment was added by Chrystomath (talk • contribs) 10:07, 27 April 2007 (UTC).[reply]

No, all NPCs are oriented the same way and the asymmetry doesn't seem to be playing a major role in the transport. See for example: Zeitler, B. & Weis, K. (2004) J. Cell Biol 167, 583–590. [1] --GKiller (talk) 14:59, 8 March 2008 (UTC)[reply]

Plug in Nuclear Pore Complex

Don't like to edit pages personally, but I'm pretty sure that the Plug in the nuclear pore complex aids the active transport of larger molecules (molecules over 25nm in diameter) into and out of the nucleus. Any thoughts? NicmaLauren (talk) 09:00, 5 December 2008 (UTC)[reply]