Talk:David A. Sinclair

Pretty lush

I don't know why, but I get the feeling that a friend of this person wrote the article. Or at least a fan. It reads like a eulogy, which is ironic because so much of his research has to do with avoiding that sort of thing. Maybe resume is a better analogy. Anyhow, I'm putting up a resume-style template message. Rhetth (talk) 03:29, 5 January 2009 (UTC)

lush alright and it's been edited by a wikipedian named davidasinclair and another one named editorboxofnumbers that know a whole lot about davidasinclair Havadmed (talk) 03:29, 16 April 2024 (UTC)

Any critique of his work can absolutely be included so long as it is in WP:RS. In fact, use of secondary independent sources is expected, rather than citing David's own primary source work. Zenomonoz (talk) 03:58, 16 April 2024 (UTC)

Mail

Hi from Germany Von: "Sinclair, David Andrew" <david_sinclair@hms.harvard.edu> An: "alia@... Datum: 22.12.2013 00:25 Hi Alia, Im David SInclair, age 44, born sydney Australia. Here is my CV. School was St. Ives High School, Sydney. Married, 3 children. Thanks, David --Alia 2005 (talk) 01:30, 22 December 2013 (UTC)

new Mail:

Von: "Sinclair, David Andrew" <david_sinclair@hms.harvard.edu> An: "alia@..." Datum: 22.12.2013 13:03 1969, June 26th. Danke --Alia 2005 (talk) 13:04, 24 December 2013 (UTC)

Professor

New Mail Von: "Sinclair, David Andrew" <david_sinclair@hms.harvard.edu> An: "alia@..." Datum: 25.12.2013 01:29 Thank you Alia! I obtained Bachelor of Science (BSc) with First Class honors at the University of New South Wales (UNSW), Sydney, Australia. Ph.D. in Biochemistry and Molecular genetics. Ph.D. = Doctor of Philosophy Yes I am a tenured professor in the Genetics Depertment of Harvard Medical School (HMS), Boston, Massachusetts Im also a co-joint Professor at the University of New South Wales (UNSW), Sydney, Australia. David Sinclair is a scientist and entrepreneur working on increasing human health, productivity, and lifespan. After co-discovering a molecular cause of aging at the Massachusetts Institute in Boston in the mid-1990s in the Laboratory of Leonard Guarente, he joined the faculty of Harvard Medical School at the age of 29 as one of their youngest faculty members, where is now a full tenured professor in the Genetics Department. In 2005, he founded the Glenn Laboratories for Aging Research and serves as their Co-Director. He co-founded the Journal Aging in 2009. He is also a Professor at the Lowy Cancer Center at the University of New South Wales in the Department of Pharmacology. His main line of research is aimed at understanding why we grow old and on using this knowledge to prevent and treat both rare and common diseases. His is perhaps best known for identifying resveratrol from red wine as an anti-aging molecule. He has founded five biotechnology companies to treat diseases (Sirtris, NASDAQ: SIRT), improve female reproductive health and IVF (OvaScience, NASDAQ: OVAS), treat type 2 diabetes (Cohbar), to develop vaccines against malaria, chlamydia, tuberculosis, pneumonia, and cancer (Genocea), and to reverse aging and age-related diseases (MetroBiotech). He spoke at TEDx and TEDMED events in 2008 and 2012. He has received numerous awards including The Australian Commonwealth Prize, the Nathan Shock Award and a MERIT Awards from the National Institutes of Health, the Merck Prize, the Genzyme Outstanding Achievement in Biomedical Science Award, the Bio-Innovator award, and Cosmos’ magazine's Bright Sparks award for Top Scientists under 40. He is featured in numerous books including "The Yough Pill" by David Stipp and "Immortal Quest" by Leonard Guarente. A fictional story was written about his research and Merry Xmas, David --Alia 2005 (talk) 04:38, 25 December 2013 (UTC)

Sirtris update

The history of Sirtris ends with the acquisition by GlaxoSmithKline in 2008. It should be mentioned that GSK shut down Sirtris in 2013. http://www.xconomy.com/boston/2013/03/12/glaxosmithkline-shuts-down-sirtris-five-years-after-720m-buyout — Preceding unsigned comment added by 37.210.161.59 (talk) 19:08, 8 January 2017 (UTC)

Sinclair article is Terribly inadequate considering importance / public interest

It's more scrubbed for politeness than informative, much less controversial, good or bad. Is this because of a trend away from text generally? To my mind Wikipedia 'must' stand up as an authoritative source. Anyway, I can list some topics I'd like to see covered (IF I can get around this HORRIBLE ARCHAIC EDITOR):

• Dr. Sinclair as showman
• Rightful successor to Durk and Sandy's ideas?
• How have Sinclairs ideas and claims aged?
• What are other luminaries past and present saying about Sinclair?

--Xgenei (talk) 02:02, 20 September 2020 (UTC)

• • How about other serious concerns, which may reflect on the claims in his "controversial" (at least!) books? See KHN.org ("A Fountain of Youth Pill? Sure, If You're A Mouse.") ELSchissel (talk) 14:45, 2 December 2020 (UTC)

    agree. and in fact someone tried to provide balance to the resveratrol claims and their stuff got reverted 116.84.110.196 (talk) 04:40, 1 May 2022 (UTC)

Reason for change to short description (Australian biogerontologist --> Australian geneticist)

There are no notable sources that I could find that call Sinclair a biogerontologist. However, there are reliable sources such as [1][2][3][4] that refer to him as a geneticist. Also, he is a professor of genetics. While Sinclair is a biogerontologist, his work focuses more on the genetic aspects of aging; biogerontology includes more than just genetics. Therefore, it would be more fitting to describe him as a geneticist. Ajshul 😃 (talk) 13:29, 23 March 2021 (UTC)

Requested move 23 March 2021

The following is a closed discussion of a requested move. Please do not modify it. Subsequent comments should be made in a new section on the talk page. Editors desiring to contest the closing decision should consider a move review after discussing it on the closer's talk page. No further edits should be made to this discussion.

The result of the move request was: moved. (non-admin closure) ~ Aseleste (t, e | c, l) 15:58, 30 March 2021 (UTC)

---

David Andrew Sinclair → David A. Sinclair – In almost all sources, David Sinclair or David A. Sinclair is used to refer to the subject, never David Andrew Sinclair (See [5] [6] [7] and also his name as the author of his book). Currently, there is a redirect at David A. Sinclair, which originally redirected to this subject's page, but then changed to a redirect to a disambiguation page with two David A. Sinclair's, one of them being this subject, and the other being a subject with no article anymore. With only this David A. Sinclair currently on Wikipedia, and with David Andrew Sinclair never really being used to refer to the subject in any sources, per WP:NCBIO and more specifically, per WP:INITS, this page should be moved there. Ajshul 😃 (talk) 15:09, 23 March 2021 (UTC) Ajshul 😃 (talk) 15:22, 23 March 2021 (UTC)

• Support per well-sourced nomination. Subject's WP:COMMONNAME is indeed David A. Sinclair, as depicted upon the cover of his book. —Roman Spinner (talk • contribs) 17:07, 23 March 2021 (UTC)

The discussion above is closed. Please do not modify it. Subsequent comments should be made on the appropriate discussion page. No further edits should be made to this discussion.

Accusations of Grifting and Fraud

Numerous attempts to reproduce Sinclair’s studies have revealed problems with his claims, and his business practices show that Sinclair has profited from these sketchy studies. 2600:8806:A624:5D00:1CD2:8338:98E6:24AD (talk) 22:20, 26 August 2024 (UTC)

Edit request

I am a colleague of David Sinclair and believe I would have a conflict of interest when editing his article. I would therefore like to make these requests on the talk page to update the current status of the article.  

The paragraph at the end of the career section states the following:

In 2024, Sinclair and his brother Nicholas Sinclair announced that their company Animal Bioscience had proven that a supplement for dogs with nondisclosed ingredients reversed aging. This claim met with widely expressed outrage in the research community. The controversy resulted in a wave of resignations from The Academy for Health and Lifespan Research, a group of scientists that Sinclair had co-founded, and Sinclair resigned as The Academy's President in March 2024.

The references used do not say “widely expressed outrage.” The Wall Street Journal also says that four people resigned, not a “wave of resignations.” I would request the paragraph be changed to the following:

In 2024, Sinclair resigned as the president of The Academy for Health and Lifespan Research, an organization he had previously co-founded. The resignation came after four resignations within the organization and outrage that was sparked from Sinclair’s announcement that Animal Bioscience had proven that a supplement for dogs with nondisclosed ingredients  reversed aging. Staringatme (talk) 21:18, 21 October 2024 (UTC)

I have done some minor tidy up. I don't think it had the major issues you argue, but I've attributed to WSJ. As a WP:RS, it does use the word "outrage". Zenomonoz (talk) 21:40, 21 October 2024 (UTC)

Thank you. I didn’t believe it was a major issue. It is just a minor detail that felt needed corrected. Staringatme (talk) 17:54, 19 November 2024 (UTC) I also apologize because I read the COI policy closer and realize I didn’t use the correct format for the request. Staringatme (talk) 17:56, 19 November 2024 (UTC)

I am a colleague of David Sinclar and requesting a change to the Wikipedia article.

The career section has a paragraph about his book. Can this be moved from the career section to the select publications section? The current career section is cluttered and I believe it would be clearer if placed into the publication section. The text is “In September 2019, Sinclair published Lifespan: Why We Age – and Why We Don't Have To co-written with journalist Matthew LaPlante and translated into 18 languages. This was also released as an audiobook on Audible and read by Sinclair. Sinclair broadly discusses his longevity practices on social media and includes them in his book. They include daily doses of nicotinamide mononucleotide (NMN) and resveratrol, which Sinclair claims are activators of SIRT1.”

Thank you for considering this request. Staringatme (talk) 17:57, 19 November 2024 (UTC)

 Done I also looked at the above request. The reference does not say "four" so wondering where that information came from. In fact, it says "cascade" which is the term that should be used on the page as we follow what the sources say. If there is different reference you are referring to, please supply it. CNMall41 (talk) 20:41, 19 November 2024 (UTC)

There appear to be more books from a quick Google Search. You are welcome to propose the addition of these if you have good sources to support (I did not dig that deep to confirm). The "Select publications" section can also be expanded, however we need to be careful about not allowing the page to read like a resume. --CNMall41 (talk) 20:45, 19 November 2024 (UTC)

Additional request?

Copying this from my talk page. @Staringatme:, please keep any additional requests you have on this page and not talk pages of individual users. It is important to see the history as Wikipedia is a collaborative environment. Also, I did not request these from you. I said that the section could be expanded but we need to be careful about it looking like a WP:NOTRESUME. I will look at these a little later. --CNMall41 (talk) 02:28, 28 November 2024 (UTC)

1. 12/15/2023: The Information Theory of Aging (https://www.researchgate.net/profile/Yuancheng-Ryan-Lu/publication/376583494_The_Information_Theory_of_Aging/links/658108cc0bb2c7472bf40381/The-Information-Theory-of-Aging.pdf)

2. 7/12/2023: Chemically induced reprogramming to reverse cellular aging (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10373966/)

3. 1/12/2023: Loss of epigenetic information as a cause of mammalian aging (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10166133/)

4. 7/5/2021: The economic value of targeting aging (https://www.nature.com/articles/s43587-021-00080-0)

5. 12/2/2020: Reprogramming to recover youthful epigenetic information and restore vision (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7752134/)

6. 11/28/2008: SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging (https://pubmed.ncbi.nlm.nih.gov/19041753/)

7. 5/2/2008: Xenohormesis: Sensing the Chemical Cues of Other Species (https://www.cell.com/cell/fulltext/S0092-8674(08)00511-4)

8. 11/1/2006: Resveratrol improves health and survival of mice on a high-calorie diet (https://www.nature.com/articles/nature05354)

9. 7/16/2004: Calorie Restriction Promotes Mammalian Cell Survival by Inducing the SIRT1 Deacetylase (https://www.researchgate.net/profile/Nathan-Wall-3/publication/8503417_Calorie_Restriction_Promotes_Mammalian_Cell_Survival_by_Inducing_the_SIRT1_Deacetylase/links/09e4150a1344269433000000/Calorie-Restriction-Promotes-Mammalian-Cell-Survival-by-Inducing-the-SIRT1-Deacetylase.pdf)

10. 11/6/2003: Yeast Life-Span Extension by Calorie Restriction Is Independent of NAD Fluctuation (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4998187/)

11. 9/11/2003: Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan (https://www.researchgate.net/profile/Robert-Zipkin/publication/10596324_Small_molecule_activators_of_sirtuins_extend_Saccharomyces_cerevisiae_lifespan/links/0fcfd5064489665462000000/Small-molecule-activators-of-sirtuins-extend-Saccharomyces-cerevisiae-lifespan.pdf)

12. 5/8/2003: Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae (https://www.nature.com/articles/nature01578)

@Staringatme:, I added the first six. Going forward, please use the talk page and edit request feature. I am more than happy to assist but again, all communication should stay here as opposed to user talk pages. Cheers!--CNMall41 (talk) 09:55, 28 November 2024 (UTC)

New Edit Request

Can the first three paragraphs be updated to the following? It is more accurate and concise with the referencing.

Sinclair met Massachusetts Institute of Technology professor Leonard P. Guarente in 1993. Guarente had studied yeast as a model of aging, and after meeting him Sinclair applied for a post-doc position in Guarente's lab. He worked as a postdoctoral researcher for Guarente for four years and in 1999 he was hired at Harvard Medical School. In 2004, Sinclair met with the philanthropist Paul F. Glenn who donated $5 million to Harvard to establish the Paul F. Glenn Laboratories for the Biological Mechanisms of Aging at Harvard, of which Sinclair became the founding director. The same year, he founded Sirtris Pharmaceuticals along with Andrew Perlman, Christoph Westphal, Richard Aldrich, Richard Pops, and Paul Schimmel.

Sirtris was focused on developing Sinclair's research into activators of sirtuins, work that began in the Guarente lab. The company was specifically focused on resveratrol formulations and derivatives as activators of the SIRT1 enzyme; Sinclair became known for making statements about resveratrol like: "(It's) as close to a miraculous molecule as you can find. ... One hundred years from now, people may be taking these molecules on a daily basis to prevent heart disease, stroke, and cancer." Most of the anti-aging field was more cautious, especially with regard to what else resveratrol might do in the body and its lack of bioavailability. The company went public in 2007 and was subsequently purchased by and made a subsidiary of GlaxoSmithKline in 2008 for $720 million. Five years later, GSK shuttered the Sirtris program without successful drug development. Staringatme (talk) 05:47, 9 December 2024 (UTC)

References

 Not done: According to the page's protection level you should be able to edit the page yourself. If you seem to be unable to, please reopen the request with further details. '''[[User:CanonNi]]''' (talk • contribs) 06:12, 9 December 2024 (UTC)

@Staringatme: While I know everyone appreciates your disclosoure of a conflict, please ensure you are using the correct request template for your edits. This page is not protected so you will not get a response to such as request. Please see WP:CIR. --CNMall41 (talk) 15:44, 9 December 2024 (UTC)

@Staringatme:, I did some clean up in anticipation of future requests and to save everyone time. I do not know if there is much left that can be done other than reducing some of the research information. Wikipedia is WP:NOTRESUME and we would only include research that is somehow notable. I did not dive deep enough into it to determine if it is/isn't so leaving for now but do not be surprised if another editor removes some of the content. Also remember that we can only include what the sources say, not what we want Wikipedia say (just a reminder about your initial The Wall Street Journal request for changing of resignation information). --CNMall41 (talk) 17:16, 9 December 2024 (UTC)

Funding

I removed the following as I am unsure of the relevance of it. CNMall41 (talk) 16:38, 9 December 2024 (UTC)

In 2015, Sinclair described to The Scientist his efforts to get funding for his lab, how his lab grew to around 20 people, shrank back down to about 5, and then grew again as he brought in funding from philanthropic organizations and companies, including companies that he helped to start. In 2015, his lab had 22 people and was supported by one R01 grant and was 75% funded by non-federal funds. However, as of 2016, this was no longer true as his federal funding began to increase.

CNMall41, I am not sure why you removed the text from The Scientist source. It is a piece specifically about Sinclair – thus relevant, no? Zenomonoz (talk) 04:36, 10 December 2024 (UTC)

I didn't really see a relevance to his lab growing, shrinking, then growing again. I guess I don't have a strong opinion either way though. Not something that would necessarily violate NPOV, just seemed trivial.--CNMall41 (talk) 20:28, 10 December 2024 (UTC)

There is also this which came out a few days ago (and some associated churnalism with it). Not sure what is relevant as I haven't dug too deep yet. --CNMall41 (talk) 20:30, 10 December 2024 (UTC)

References