Talk:Allopregnanolone

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Fairly unknown substance at this point in time

I have merged "allopregnanolone" and "brexanolone" as they are the same thing. With both being mostly unknown spitting them at this point in time will result in confusion more than anything and it is not like there is too much content on the topic. Doc James (talk · contribs · email) 10:23, 23 March 2019 (UTC)[reply]

It should be removed , the article sounds like an advert for brexanolone, the article starts with allopregnanolone being stated as a medication before a natural substance. This is clearly unethical editing of the original article. You can speak of brexanolone later in the article, right now it looks like the pharma companies marketing department edited the page on a naturally occurring neurosteroid, the context of my points stem from the fact that brexanolone cost up to 30,000 dollars for a course of treatment, convenient this isn’t mentioned in the article, there is clearly an agenda with the editing of this article, many women would have come to this page when they heard about brexanolone and this page is designed to mislead in my opinion. — Preceding unsigned comment added by 84.247.48.29 (talk) 23:42, 1 March 2020 (UTC) drareg[reply]

@84.247.48.29: Quoted from the lead of the article: "The long administration time, as well as the cost of US$34,000, have raised concerns about accessibility for many women." –Erakura^(talk) 23:50, 1 March 2020 (UTC)[reply]

Should we now go to the page on the thyroid gland and edit it in a similar fashion to the allopreganolone page? Shall we start with-triiodothyronine (t3) is a medication and naturally occurring steroid, we can then go on for 3 paragraphs about a pharmaceutical brand of T3? Do you get the logic here,millions of women suffering postpartum depression will be looking at this page and it’s misleading,provide a separate link and article on brexanolone,when searched via google triiodothyronine does not lead to an article on a pharma branded medicine. These are supposed to be scientific articles,does that count for anything anymore,do we understand what that even means? The doctor editing this page whimsically passes them off as the same thing,this is completely delusional and I feel strongly it’s intentionally misleading on behalf of the "brand" brenaxolone.Drareg.

brexanolone

Not sure why this was removed?

This text is unreffed "Allopregnanolone and synthetic variants have pharmacology similar to the barbiturates, acting at GABA A ion channels, with large doses leading to CNS depression and potential death. External dosing of these compounds is also associated with tolerance and self-administration, and as such are considered DEA controlled substances, like benzodiazepines and barbiturates." Doc James (talk · contribs · email) 06:17, 2 September 2019 (UTC)[reply]

It should be removed , the article sounds like an advert for brexanolone, the article starts with allopregnanolone being stated as a medication before a natural substance. This is clearly unethical editing of the original article. You can speak of brexanolone later in the article, right now it looks like the pharma companies marketing department edited the page on a naturally occurring neurosteroid, the context of my points stem from the fact that brexanolone cost up to 30,000 dollars for a course of treatment, convenient this isn’t mentioned in the article, there is clearly an agenda with the editing of this article, many women would have come to this page when they heard about brexanolone and this page is designed to mislead in my opinion.

Which text do you consider an advert? Doc James (talk · contribs · email) 00:46, 2 March 2020 (UTC)[reply]

Move

Wondering if we should move to the INN which is brexanolone per [1]? Doc James (talk · contribs · email) 14:03, 3 September 2019 (UTC)[reply]

I agree. "Brexanolone" is the approved generic name (both the INN and the USAN according to https://www.genome.jp/dbget-bin/www_bget?dr:D11149). Guidelines at Wikipedia:WikiProject Pharmacology/Style guide suggest Brexanolone is therefore the appropriate title. -- Ed (Edgar181) 12:59, 4 September 2019 (UTC)[reply]

Adding mention of zuranolone to article and where to add

To me, zuranolone clearly needs to be mentioned in this article. They are extremely similar in structure (neurosteroid), have the same MOA (GABAA positive allosteric modulator), and are FDA-approved for the same condition (postpartum depression). I think the question is, where should it be added? Should it be added in the intro, "MOA" section, "Derivatives" section, or create a new "See also" section and list it there? Thanks! Wikipedialuva (talk) 08:01, 20 October 2023 (UTC)[reply]