Steven C. Hebert

Dr. Steven Hebert
Dr. Steven Hebert
Born	1946; Rockford, Illinois
Died	April 15, 2008
Nationality	American
Alma mater	Florida State University; University of Florida
Known for	His work in nephrology
Spouse	Patricia Hebert

Steven C. Hebert, M.D., (b. 1946 in Rockford, Illinois—d. April 15, 2008), a board certified nephrologist, was the chair and C.N.H. Long Professor of Cellular and Molecular Physiology and professor of medicine at Yale University, beginning in 2000.^[1]^[2] ^[3]^[4]

Education

Hebert entered Florida State University at age 15 and earned a bachelor's degree in three years. He then obtained an M.D. at the University of Florida in 1970. He went on to complete his residency in internal medicine and a nephrology fellowship at the University of Alabama in Birmingham.

Career

Before coming to Yale, Hebert was a faculty member at the University of Alabama in Birmingham, Eastern Virginia Medical School, the University of Texas Medical School at Houston, Harvard Medical School, and Vanderbilt University as director of the Division of Nephrology and the Ann and Roscoe R. Robinson Professor of Medicine.

With colleagues, he launched the biotech companies MariCal and Pearl Development Group.

His laboratory identified ROMK, a potassium excretion regulatory channel in the kidney outer medulla involved in Bartter's syndrome type II,^[5]^[6] two sodium chloride transporters,^[7] and a calcium-sensing receptor known as CaSR which led to the development of a new class of drugs that modulate calcium sensing receptor activity.^[8]

Honors

Homer W. Smith Award, top research prize, by the American Society of Nephrology.
A.N. Richards Award, the International Society of Nephrology.
Carl W. Gottschalk Distinguished Lectureship, American Society of Physiology.
Member, American Society for Clinical Investigation in 1988.
Member, Association of American Physicians in 1993.
Elected to the National Academy of Sciences in 2005.

References

^ Ho, K.; Nichols, C. G.; Lederer, W. J.; Lytton, J.; Vassilev, P. M.; Kanazirska, M. V.; Hebert, S. C. (1993). "Cloning and expression of an inwardly rectifying ATP-regulated potassium channel". Nature. 362 (6415): 31–8. Bibcode:1993Natur.362...31H. doi:10.1038/362031a0. PMID 7680431. S2CID 4332298.
^ Hebert Obituary at Yale Archived 2008-06-30 at the Wayback Machine
^ Trivedi, B. P. (2006). "Profile of Steven C. Hebert". Proceedings of the National Academy of Sciences. 103 (25): 9387–9389. Bibcode:2006PNAS..103.9387T. doi:10.1073/pnas.0604149103. PMC 1480417. PMID 16772375.
^ Andreoli, T. E. (2008). "An obituary for Steven C. Hebert, MD". Journal of the American Society of Nephrology. 19 (7): 1247–8. doi:10.1681/ASN.2008050457. PMID 18579637.
^ Ho, Kevin; Nichols, Colin G.; Lederer, W. Jonathan; Lytton, Jonathan; Vassilev, Peter M.; Kanazirska, Marie V.; Hebert, Steven C. (1993-03-04). "Cloning and expression of an inwardly rectifying ATP-regulated potassium channel". Nature. 362 (6415): 31–38. doi:10.1038/362031a0. ISSN 0028-0836.
^ Simon, David B.; Karet, Fiona E.; Rodriguez-Soriano, Juan; Hamdan, Jahed H.; DiPietro, Antonio; Trachtman, Howard; Sanjad, Sami A.; Lifton, Richard P. (1996-10-01). "Genetic heterogeneity of Barter's syndrome revealed by mutations in the K+ channel, ROMK". Nature Genetics. 14 (2): 152–156. doi:10.1038/ng1096-152. ISSN 1061-4036.
^ Gamba, G.; Miyanoshita, A.; Lombardi, M.; Lytton, J.; Lee, W.S.; Hediger, M.A.; Hebert, S.C. (1994-07-01). "Molecular cloning, primary structure, and characterization of two members of the mammalian electroneutral sodium-(potassium)-chloride cotransporter family expressed in kidney". Journal of Biological Chemistry. 269 (26): 17713–17722. doi:10.1016/S0021-9258(17)32499-7.
^ Brown, Edward M.; Gamba, Gerardo; Riccardi, Daniela; Lombardi, Michael; Butters, Robert; Kifor, Olga; Sun, Adam; Hediger, Matthias A.; Lytton, Jonathan; Hebert, Steven C. (1993-12-09). "Cloning and characterization of an extracellular Ca2+-sensing receptor from bovine parathyroid". Nature. 366 (6455): 575–580. doi:10.1038/366575a0. ISSN 0028-0836.

[1] Ho, K.; Nichols, C. G.; Lederer, W. J.; Lytton, J.; Vassilev, P. M.; Kanazirska, M. V.; Hebert, S. C. (1993). "Cloning and expression of an inwardly rectifying ATP-regulated potassium channel". Nature. 362 (6415): 31–8. Bibcode:1993Natur.362...31H. doi:10.1038/362031a0. PMID 7680431. S2CID 4332298.

[2] Hebert Obituary at Yale Archived 2008-06-30 at the Wayback Machine

[3] Trivedi, B. P. (2006). "Profile of Steven C. Hebert". Proceedings of the National Academy of Sciences. 103 (25): 9387–9389. Bibcode:2006PNAS..103.9387T. doi:10.1073/pnas.0604149103. PMC 1480417. PMID 16772375.

[4] Andreoli, T. E. (2008). "An obituary for Steven C. Hebert, MD". Journal of the American Society of Nephrology. 19 (7): 1247–8. doi:10.1681/ASN.2008050457. PMID 18579637.

[5] Ho, Kevin; Nichols, Colin G.; Lederer, W. Jonathan; Lytton, Jonathan; Vassilev, Peter M.; Kanazirska, Marie V.; Hebert, Steven C. (1993-03-04). "Cloning and expression of an inwardly rectifying ATP-regulated potassium channel". Nature. 362 (6415): 31–38. doi:10.1038/362031a0. ISSN 0028-0836.

[6] Simon, David B.; Karet, Fiona E.; Rodriguez-Soriano, Juan; Hamdan, Jahed H.; DiPietro, Antonio; Trachtman, Howard; Sanjad, Sami A.; Lifton, Richard P. (1996-10-01). "Genetic heterogeneity of Barter's syndrome revealed by mutations in the K+ channel, ROMK". Nature Genetics. 14 (2): 152–156. doi:10.1038/ng1096-152. ISSN 1061-4036.

[7] Gamba, G.; Miyanoshita, A.; Lombardi, M.; Lytton, J.; Lee, W.S.; Hediger, M.A.; Hebert, S.C. (1994-07-01). "Molecular cloning, primary structure, and characterization of two members of the mammalian electroneutral sodium-(potassium)-chloride cotransporter family expressed in kidney". Journal of Biological Chemistry. 269 (26): 17713–17722. doi:10.1016/S0021-9258(17)32499-7.

[8] Brown, Edward M.; Gamba, Gerardo; Riccardi, Daniela; Lombardi, Michael; Butters, Robert; Kifor, Olga; Sun, Adam; Hediger, Matthias A.; Lytton, Jonathan; Hebert, Steven C. (1993-12-09). "Cloning and characterization of an extracellular Ca2+-sensing receptor from bovine parathyroid". Nature. 366 (6455): 575–580. doi:10.1038/366575a0. ISSN 0028-0836.

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