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SULF2

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SULF2
Identifiers
AliasesSULF2, HSULF-2, sulfatase 2
External IDsOMIM: 610013; MGI: 1919293; HomoloGene: 10313; GeneCards: SULF2; OMA:SULF2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001161841
NM_018837
NM_198596

NM_001252578
NM_001252579
NM_028072
NM_001355619

RefSeq (protein)

NP_001155313
NP_061325
NP_940998

NP_001239507
NP_001239508
NP_082348
NP_001342548

Location (UCSC)Chr 20: 47.66 – 47.79 MbChr 2: 165.92 – 166 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Extracellular sulfatase Sulf-2 is an enzyme that in humans is encoded by the SULF2 gene.[5][6]

Function

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Heparan sulfate proteoglycans (HSPGs) act as coreceptors for numerous heparin-binding growth factors and cytokines and are involved in cell signaling. Heparan sulfate 6-O-endosulfatases, such as SULF2, selectively remove 6-O-sulfate groups from heparan sulfate. This activity modulates the effects of heparan sulfate by altering binding sites for signaling molecules (Dai et al., 2005).[supplied by OMIM][6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000196562Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000006800Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Morimoto-Tomita M, Uchimura K, Werb Z, Hemmerich S, Rosen SD (December 2002). "Cloning and characterization of two extracellular heparin-degrading endosulfatases in mice and humans". The Journal of Biological Chemistry. 277 (51): 49175–49185. doi:10.1074/jbc.M205131200. PMC 2779716. PMID 12368295.
  6. ^ a b "Entrez Gene: SULF2 sulfatase 2".

Further reading

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