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PPM1F

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PPM1F
Identifiers
AliasesPPM1F, CAMKP, CaMKPase, FEM-2, POPX2, hFEM-2, protein phosphatase, Mg2+/Mn2+ dependent 1F
External IDsMGI: 1918464; HomoloGene: 22828; GeneCards: PPM1F; OMA:PPM1F - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_014634

NM_176833

RefSeq (protein)

NP_055449

NP_789803

Location (UCSC)Chr 22: 21.92 – 21.95 MbChr 16: 16.71 – 16.75 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Protein phosphatase 1F is an enzyme that in humans is encoded by the PPM1F gene.[5][6][7]

The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase can interact with Rho guanine nucleotide exchange factors (PIX), and thus block the effects of p21-activated kinase 1 (PAK), a protein kinase mediating biological effects downstream of Rho GTPases. Calcium/calmodulin-dependent protein kinase II gamma (CAMK2G/CAMK-II) is found to be one of the substrates of this phosphatase. The overexpression of this phosphatase or CAMK2G has been shown to mediate caspase-dependent apoptosis. An alternatively spliced transcript variant has been identified, but its full-length nature has not been determined.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000100034Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026181Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Koh CG, Tan EJ, Manser E, et al. (Feb 2002). "The p21-activated kinase PAK is negatively regulated by POPX1 and POPX2, a pair of serine/threonine phosphatases of the PP2C family". Curr Biol. 12 (4): 317–21. Bibcode:2002CBio...12..317K. doi:10.1016/S0960-9822(02)00652-8. PMID 11864573.
  6. ^ Tan KM, Chan SL, Tan KO, et al. (Nov 2001). "The Caenorhabditis elegans sex-determining protein FEM-2 and its human homologue, hFEM-2, are Ca2+/calmodulin-dependent protein kinase phosphatases that promote apoptosis". J Biol Chem. 276 (47): 44193–202. doi:10.1074/jbc.M105880200. PMID 11559703.
  7. ^ a b "Entrez Gene: PPM1F protein phosphatase 1F (PP2C domain containing)".

Further reading

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