From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Polymerase delta-interacting protein 3 is an enzyme that in humans is encoded by the POLDIP3 gene .[ 5] [ 6]
This gene encodes a protein that interacts with the DNA polymerase delta p50 subunit. This protein is a specific target of S6 kinase 1 and regulates cell growth. Two transcript variants that encode different protein isoforms have been identified.[ 6]
POLDIP3 has been shown to interact with P70-S6 Kinase 1 .[ 7]
^ a b c GRCh38: Ensembl release 89: ENSG00000100227 – Ensembl , May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000041815 – Ensembl , May 2017
^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Liu L, Rodriguez-Belmonte EM, Mazloum N, Xie B, Lee MY (Mar 2003). "Identification of a novel protein, PDIP38, that interacts with the p50 subunit of DNA polymerase delta and proliferating cell nuclear antigen" . J Biol Chem . 278 (12): 10041– 7. doi :10.1074/jbc.M208694200 . PMID 12522211 .
^ a b "Entrez Gene: POLDIP3 polymerase (DNA-directed), delta interacting protein 3" .
^ Richardson CJ, Bröenstrup Mark, Fingar Diane C, Jülich Kristina, Ballif Bryan A, Gygi Steven, Blenis John (Sep 2004). "SKAR is a specific target of S6 kinase 1 in cell growth control" . Curr. Biol . 14 (17). England: 1540– 9. Bibcode :2004CBio...14.1540R . doi :10.1016/j.cub.2004.08.061 . ISSN 0960-9822 . PMID 15341740 .
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Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899– 903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 . PMC 139241 . PMID 12477932 .
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Richardson CJ, Bröenstrup M, Fingar DC, et al. (2005). "SKAR is a specific target of S6 kinase 1 in cell growth control" . Curr. Biol . 14 (17): 1540– 9. Bibcode :2004CBio...14.1540R . doi :10.1016/j.cub.2004.08.061 . PMID 15341740 .
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Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121– 7. doi :10.1101/gr.2596504 . PMC 528928 . PMID 15489334 .
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Smyk A, Szuminska M, Uniewicz KA, et al. (2006). "Human enhancer of rudimentary is a molecular partner of PDIP46/SKAR, a protein interacting with DNA polymerase delta and S6K1 and regulating cell growth" . FEBS J . 273 (20): 4728– 41. doi :10.1111/j.1742-4658.2006.05477.x . PMID 16984396 .