Nasal embryonic LHRH factor

NSMF
Identifiers
Aliases	NSMF, HH9, NELF, Nasal embryonic LHRH factor, NMDA receptor synaptonuclear signaling and neuronal migration factor
External IDs	OMIM: 608137; MGI: 1861755; HomoloGene: 10648; GeneCards: NSMF; OMA:NSMF - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	137,459,334 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	24,952,893 bp
RNA expression pattern
	Top expressed in
	anterior cingulate cortex; ; right frontal lobe; ; amygdala; ; prefrontal cortex; ; Region I of hippocampus proper; ; ascending aorta; ; dorsolateral prefrontal cortex; ; caudate nucleus; ; Descending thoracic aorta; ; nucleus accumbens;
	Top expressed in
	medial dorsal nucleus; ; medial geniculate nucleus; ; lateral geniculate nucleus; ; subiculum; ; anterior amygdaloid area; ; barrel cortex; ; suprachiasmatic nucleus; ; substantia nigra; ; olfactory tubercle; ; prefrontal cortex;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	calcium-dependent protein binding;
Cellular component	cytoplasm; apical dendrite; perikaryon; postsynaptic membrane; cell projection; nuclear membrane; nuclear envelope; membrane; postsynaptic density; nuclear matrix; cortical cytoskeleton; plasma membrane; synapse; nucleoplasm; cell junction; dendrite; cell cortex; neuron projection; cytoskeleton; nucleus;
Biological process	positive regulation of protein dephosphorylation; regulation of neuron apoptotic process; positive regulation of neuron migration; regulation of dendrite morphogenesis; cellular response to amino acid stimulus; cellular response to gonadotropin stimulus; cellular response to electrical stimulus; regulation of neuron migration; regulation of neuronal synaptic plasticity;
	Sources:Amigo / QuickGO
Orthologs
	26012
	56876
	ENSG00000165802
	ENSMUSG00000006476
	Q6X4W1
	Q99NF2
	NM_001130969; NM_001130970; NM_001130971; NM_001178064; NM_015537
	NM_001039386; NM_001039387; NM_001177654; NM_001177655; NM_020276
	NP_001124441; NP_001124442; NP_001124443; NP_001171535; NP_056352
	NP_001034475; NP_001034476; NP_001171125; NP_001171126; NP_064672
	Wikidata
View/Edit Human	View/Edit Mouse

Nasal embryonic luteinizing hormone-releasing hormone factor is a protein that in humans is encoded by the NELF gene.^[5]^[6]^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000165802 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000006476 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
^ Kramer PR, Wray S (Jul 2000). "Novel gene expressed in nasal region influences outgrowth of olfactory axons and migration of luteinizing hormone-releasing hormone (LHRH) neurons". Genes & Development. 14 (14): 1824–34. doi:10.1101/gad.14.14.1824. PMC 316793. PMID 10898796.
^ "Entrez Gene: NELF nasal embryonic LHRH factor".

Miura K, Acierno JS, Seminara SB (2004). "Characterization of the human nasal embryonic LHRH factor gene, NELF, and a mutation screening among 65 patients with idiopathic hypogonadotropic hypogonadism (IHH)". Journal of Human Genetics. 49 (5): 265–8. doi:10.1007/s10038-004-0137-4. PMID 15362570.
Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R (Apr 2006). "Phosphoproteome analysis of the human mitotic spindle". Proceedings of the National Academy of Sciences of the United States of America. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY (May 2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000165802 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000006476 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11230166-5] Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.

[pmid10898796-6] Kramer PR, Wray S (Jul 2000). "Novel gene expressed in nasal region influences outgrowth of olfactory axons and migration of luteinizing hormone-releasing hormone (LHRH) neurons". Genes & Development. 14 (14): 1824–34. doi:10.1101/gad.14.14.1824. PMC 316793. PMID 10898796.

[entrez-7] "Entrez Gene: NELF nasal embryonic LHRH factor".

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References

Further reading