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Michelle Chang (biochemist)

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Michelle Chia-yu Chang
Born1977 (age 46–47)
San Diego, California, U.S.
Alma materUniversity of California, San Diego (BS, BA)
Massachusetts Institute of Technology (PhD)
SpouseChristopher Chang
Scientific career
FieldsMetabolic engineering
Synthetic biology
InstitutionsUniversity of California, Berkeley
ThesisProton-coupled electron transfer in the Escherichia coli ribonucleotide reductase (2004)
Doctoral advisorJoAnne Stubbe
Daniel G. Nocera
Other academic advisorsJay Keasling
Websitewww.cchem.berkeley.edu/mccgrp/publications.html

Michelle C. Y. Chang (born 1977) is a Professor of Chemistry and Chemical and Biomolecular Engineering at the University of California, Berkeley, and is a recipient of several young scientist awards for her research in biosynthesis of biofuels and pharmaceuticals.[1]

Education

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Chang received her B.S. in biochemistry and B.A. in French literature from the University of California, San Diego, in 1997.

She then moved to the Massachusetts Institute of Technology for graduate school as a National Science Foundation Predoctoral Fellow (1997-2000) and M.I.T./Merck Foundation Predoctoral Fellow (2000-2002). She earned her Ph.D. in 2004 under the direction of JoAnne Stubbe and Daniel G. Nocera. During her graduate work, Chang studied proton-coupled electron transfer processes in ribonucleotide reductase enzymes, and demonstrated the first direct evidence of the radical transfer pathway of class I RNRs.[2][3][4]

Following graduate school, she conducted research as a Jane Coffin Childs Memorial Fund for Medical Research Postdoctoral Fellow at University of California, Berkeley with Jay Keasling (2004-2007). At Berkeley, Chang studied enzyme-catalyzed reactions, demonstrating that by expressing plant P450 enzymes in bacteria like E. coli, the E. coli could be engineered to produce terpenoids, a class of natural products often found in drugs.[5][6] Chang began her independent career at UC Berkeley in 2007.

Awards

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Personal life

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Michelle was born in San Diego, California, to Chinese immigrant parents from Taiwan.[14] She is married to her colleague in the College of Chemistry, Christopher Chang.[15]

Publications

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Chang's scientific papers are listed on her group's website.

References

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  1. ^ a b c "Faculty & Research - College of Chemistry". chem.berkeley.edu.
  2. ^ Chang, Michelle C. Y. (Michelle Chia-yu) (2004). Proton-coupled electron transfer in the Escherichia coli ribonucleotide reductase (Thesis). Massachusetts Institute of Technology. hdl:1721.1/30067.
  3. ^ Chang, Michelle C. Y.; Yee, Cyril S.; Stubbe, JoAnne; Nocera, Daniel G. (2004-05-04). "Turning on ribonucleotide reductase by light-initiated amino acid radical generation". Proceedings of the National Academy of Sciences. 101 (18): 6882–6887. Bibcode:2004PNAS..101.6882C. doi:10.1073/pnas.0401718101. ISSN 0027-8424. PMC 406436. PMID 15123822.
  4. ^ Chang, Michelle C. Y.; Yee, Cyril S.; Nocera, Daniel G.; Stubbe, JoAnne (2004-12-01). "Site-Specific Replacement of a Conserved Tyrosine in Ribonucleotide Reductase with an Aniline Amino Acid: A Mechanistic Probe for a Redox-Active Tyrosine". Journal of the American Chemical Society. 126 (51): 16702–16703. doi:10.1021/ja044124d. ISSN 0002-7863. PMID 15612690.
  5. ^ "Michelle Chang: A catalyst for change". The Scientist Magazine®. Retrieved 2021-05-15.
  6. ^ Chang, Michelle C. Y.; Eachus, Rachel A.; Trieu, William; Ro, Dae-Kyun; Keasling, Jay D. (2007). "Engineering Escherichia coli for production of functionalized terpenoids using plant P450s". Nature Chemical Biology. 3 (5): 274–277. doi:10.1038/nchembio875. ISSN 1552-4469. PMID 17438551.
  7. ^ Review, MIT Technology. "Innovator Under 35: Michelle Chang, 31". MIT Technology Review.
  8. ^ CAREER award Archived 2011-09-28 at the Wayback Machine
  9. ^ Agilent Early Career Award Archived 2011-09-28 at the Wayback Machine
  10. ^ International Young Talents Archived 2011-09-28 at the Wayback Machine
  11. ^ "UC Berkeley, College of Chemistry - News and Publications - Chang and Hammond win NIH New Innovator Awards". Archived from the original on 2011-12-09. Retrieved 2011-10-20.
  12. ^ "2012 Agnes Fay Morgan Research Award, Dr Michelle Chang" (PDF). iotasigmapi.info.
  13. ^ "2015 National Award Recipients". American Chemical Society. Retrieved 2016-03-20.
  14. ^ "財經新聞 - PChome 新聞". PChome 新聞.
  15. ^ "National magazines tout two chemists and two astronomers as top innovators in their fields" Archived 2011-06-13 at the Wayback Machine, UC Newsroom, August 22, 2008 (retrieved January 26, 2010)


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