MOGAT2

MOGAT2
Identifiers
Aliases	MOGAT2, DGAT2L5, MGAT2, DGAT2L5., hDC5, monoacylglycerol O-acyltransferase 2
External IDs	OMIM: 610270; MGI: 2663253; HomoloGene: 57020; GeneCards: MOGAT2; OMA:MOGAT2 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	75,732,958 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	98,887,826 bp
RNA expression pattern
	Top expressed in
	mucosa of ileum; ; mucosa of transverse colon; ; right lobe of liver; ; testicle; ; rectum; ; jejunal mucosa; ; duodenum; ; mucosa of sigmoid colon; ; epithelium of colon; ; appendix;
	Top expressed in
	epithelium of small intestine; ; intestinal villus; ; ileum; ; jejunum; ; yolk sac; ; duodenum; ; primitive streak; ; migratory enteric neural crest cell; ; epiblast; ; somite;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; acetyltransferase activity; acyltransferase activity; acyltransferase activity, transferring groups other than amino-acyl groups; 2-acylglycerol O-acyltransferase activity;
Cellular component	integral component of membrane; endoplasmic reticulum; membrane; endoplasmic reticulum membrane;
Biological process	intestinal absorption; glycerol metabolic process; diacylglycerol biosynthetic process; lipid metabolism; triglyceride biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	80168
	233549
	ENSG00000166391
	ENSMUSG00000052396
	Q3SYC2
	Q80W94
	NM_025098
	NM_177448
	NP_079374
	NP_803231
	Wikidata
View/Edit Human	View/Edit Mouse

2-Acylglycerol O-acyltransferase 2 also known as acyl-CoA:monoacylglycerol acyltransferase 2 (MGAT2) or Diacylglycerol O-acyltransferase candidate 5 (DC5) is an enzyme that in humans is encoded by the MOGAT2 gene.

MOGAT2 and the related MOGAT3 genes are members of the acylglycerol o-acyltransferase family (DGAT2/MOGAT) and are involved in the synthesis of diacylglycerol (DAG) and triacylglycerol (TAG) from monoacylglycerol (MAG).

MOGAT2 and also MOGAT3 are single copy genes in almost all mammals. However, in ruminants both genes have undergone tandem gene expansion, indicate of evolving functionality. MOGAT2 has more than five tandemly duplicated copies in sheep with the first copy expressed in the duodenum and the last copy expressed in the skin, with no expression of any copy detected in the liver.^[5]^[6]^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000166391 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000052396 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Winter A, van Eckeveld M, Bininda-Emonds OR, Habermann FA, Fries R (Feb 2004). "Genomic organization of the DGAT2/MOGAT gene family in cattle (Bos taurus) and other mammals". Cytogenetic and Genome Research. 102 (1–4): 42–7. doi:10.1159/000075723. PMID 14970677. S2CID 25524277.
^ "Entrez Gene: MOGAT2 monoacylglycerol O-acyltransferase 2".
^ Jiang Y, Xie M, Chen W, Talbot R, Maddox JF, Faraut T, Wu C, Muzny DM, Li Y, Zhang W, Stanton JA, Brauning R, Barris WC, Hourlier T, Aken BL, Searle SM, Adelson DL, Bian C, Cam GR, Chen Y, Cheng S, DeSilva U, Dixen K, Dong Y, Fan G, Franklin IR, Fu S, Fuentes-Utrilla P, Guan R, Highland MA, Holder ME, Huang G, Ingham AB, Jhangiani SN, Kalra D, Kovar CL, Lee SL, Liu W, Liu X, Lu C, Lv T, Mathew T, McWilliam S, Menzies M, Pan S, Robelin D, Servin B, Townley D, Wang W, Wei B, White SN, Yang X, Ye C, Yue Y, Zeng P, Zhou Q, Hansen JB, Kristiansen K, Gibbs RA, Flicek P, Warkup CC, Jones HE, Oddy VH, Nicholas FW, McEwan JC, Kijas JW, Wang J, Worley KC, Archibald AL, Cockett N, Xu X, Wang W, Dalrymple BP (Jun 2014). "The sheep genome illuminates biology of the rumen and lipid metabolism". Science. 344 (6188): 1168–73. Bibcode:2014Sci...344.1168J. doi:10.1126/science.1252806. PMC 4157056. PMID 24904168.

Cao J, Hawkins E, Brozinick J, Liu X, Zhang H, Burn P, Shi Y (Apr 2004). "A predominant role of acyl-CoA:monoacylglycerol acyltransferase-2 in dietary fat absorption implicated by tissue distribution, subcellular localization, and up-regulation by high fat diet". The Journal of Biological Chemistry. 279 (18): 18878–86. doi:10.1074/jbc.M313272200. PMID 14966132.
Lockwood JF, Cao J, Burn P, Shi Y (Nov 2003). "Human intestinal monoacylglycerol acyltransferase: differential features in tissue expression and activity". American Journal of Physiology. Endocrinology and Metabolism. 285 (5): E927–37. doi:10.1152/ajpendo.00179.2003. PMID 12824082.
Yen CL, Farese RV (May 2003). "MGAT2, a monoacylglycerol acyltransferase expressed in the small intestine". The Journal of Biological Chemistry. 278 (20): 18532–7. doi:10.1074/jbc.M301633200. PMID 12621063.
Cao J, Lockwood J, Burn P, Shi Y (Apr 2003). "Cloning and functional characterization of a mouse intestinal acyl-CoA:monoacylglycerol acyltransferase, MGAT2". The Journal of Biological Chemistry. 278 (16): 13860–6. doi:10.1074/jbc.M300139200. PMID 12576479.

This article on a gene on human chromosome 11 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000166391 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000052396 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid14970677-5] Winter A, van Eckeveld M, Bininda-Emonds OR, Habermann FA, Fries R (Feb 2004). "Genomic organization of the DGAT2/MOGAT gene family in cattle (Bos taurus) and other mammals". Cytogenetic and Genome Research. 102 (1–4): 42–7. doi:10.1159/000075723. PMID 14970677. S2CID 25524277.

[entrez-6] "Entrez Gene: MOGAT2 monoacylglycerol O-acyltransferase 2".

[The_Sheep_Genome-7] Jiang Y, Xie M, Chen W, Talbot R, Maddox JF, Faraut T, Wu C, Muzny DM, Li Y, Zhang W, Stanton JA, Brauning R, Barris WC, Hourlier T, Aken BL, Searle SM, Adelson DL, Bian C, Cam GR, Chen Y, Cheng S, DeSilva U, Dixen K, Dong Y, Fan G, Franklin IR, Fu S, Fuentes-Utrilla P, Guan R, Highland MA, Holder ME, Huang G, Ingham AB, Jhangiani SN, Kalra D, Kovar CL, Lee SL, Liu W, Liu X, Lu C, Lv T, Mathew T, McWilliam S, Menzies M, Pan S, Robelin D, Servin B, Townley D, Wang W, Wei B, White SN, Yang X, Ye C, Yue Y, Zeng P, Zhou Q, Hansen JB, Kristiansen K, Gibbs RA, Flicek P, Warkup CC, Jones HE, Oddy VH, Nicholas FW, McEwan JC, Kijas JW, Wang J, Worley KC, Archibald AL, Cockett N, Xu X, Wang W, Dalrymple BP (Jun 2014). "The sheep genome illuminates biology of the rumen and lipid metabolism". Science. 344 (6188): 1168–73. Bibcode:2014Sci...344.1168J. doi:10.1126/science.1252806. PMC 4157056. PMID 24904168.

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References

Further reading