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Lethal(3)malignant brain tumor-like protein
L3MBTL1 Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1OYX , 1OZ2 , 1OZ3 , 2PQW , 2RHI , 2RHU , 2RHX , 2RHY , 2RHZ , 2RI2 , 2RI3 , 2RI5 , 2RJC , 2RJD , 2RJE , 2RJF , 3OQ5 , 3P8H , 3UWN
Identifiers Aliases L3MBTL1 External IDs OMIM : 608802 ; MGI : 2676663 ; HomoloGene : 41846 ; GeneCards : L3MBTL1 ; OMA :L3MBTL1 - orthologs Wikidata
Lethal(3)malignant brain tumor-like protein is a protein that in humans is encoded by the L3MBTL gene .[ 5] [ 6] [ 7]
This gene encodes the homolog of a protein identified in Drosophila as a suppressor of malignant transformation of neuroblasts and ganglion mother cells in the optic centers of the brain. This gene product is localized to condensed chromosomes in mitotic cells. Overexpression of this gene in a glioma cell line results in improper nuclear segregation and cytokinesis producing multinucleated cells. Alternatively spliced transcript variants encoding different isoforms have been identified.[ 7]
^ a b c GRCh38: Ensembl release 89: ENSG00000185513 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000035576 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Koga H, Matsui S, Hirota T, Takebayashi S, Okumura K, Saya H (Sep 1999). "A human homolog of Drosophila lethal(3)malignant brain tumor (l(3)mbt) protein associates with condensed mitotic chromosomes". Oncogene . 18 (26): 3799–809. doi :10.1038/sj.onc.1202732 . PMID 10445843 . S2CID 8186230 . ^ Trojer P, Li G, Sims RJ III, Vaquero A, Kalakonda N, Boccuni P, Lee D, Erdjument-Bromage H, Tempst P, Nimer SD, Wang YH, Reinberg D (Jun 2007). "L3MBTL1, a histone-methylation-dependent chromatin lock" . Cell . 129 (5): 915–28. doi :10.1016/j.cell.2007.03.048 PMID 17540172 . S2CID 16425537 . ^ a b "Entrez Gene: L3MBTL l(3)mbt-like (Drosophila)" .
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . MacGrogan D, Kalakonda N, Alvarez S, et al. (2004). "Structural integrity and expression of the L3MBTL gene in normal and malignant hematopoietic cells". Genes Chromosomes Cancer . 41 (3): 203–13. doi :10.1002/gcc.20087 . PMID 15334543 . S2CID 35563365 . Li J, Bench AJ, Vassiliou GS, et al. (2004). "Imprinting of the human L3MBTL gene, a polycomb family member located in a region of chromosome 20 deleted in human myeloid malignancies" . Proc. Natl. Acad. Sci. U.S.A . 101 (19): 7341–6. Bibcode :2004PNAS..101.7341L . doi :10.1073/pnas.0308195101 PMC 409920 PMID 15123827 . Wang WK, Tereshko V, Boccuni P, et al. (2004). "Malignant brain tumor repeats: a three-leaved propeller architecture with ligand/peptide binding pockets" . Structure . 11 (7): 775–89. doi :10.1016/S0969-2126(03)00127-8 . PMC 4693639 PMID 12842041 . Boccuni P, MacGrogan D, Scandura JM, Nimer SD (2003). "The human L(3)MBT polycomb group protein is a transcriptional repressor and interacts physically and functionally with TEL (ETV6)" . J. Biol. Chem . 278 (17): 15412–20. doi :10.1074/jbc.M300592200 PMID 12588862 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20" . Nature . 414 (6866): 865–71. Bibcode :2001Natur.414..865D . doi :10.1038/414865a PMID 11780052 . Fossey SC, Mychaleckyj JC, Pendleton JK, et al. (2001). "A high-resolution 6.0-megabase transcript map of the type 2 diabetes susceptibility region on human chromosome 20" . Genomics . 76 (1–3): 45–57. doi :10.1006/geno.2001.6584 . PMID 11549316 . Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags" . Proc. Natl. Acad. Sci. U.S.A . 97 (7): 3491–6. Bibcode :2000PNAS...97.3491D . doi :10.1073/pnas.97.7.3491 PMC 16267 PMID 10737800 . Ishikawa K, Nagase T, Suyama M, et al. (1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro" . DNA Res . 5 (3): 169–76. doi :10.1093/dnares/5.3.169 PMID 9734811 .
Overview of all the structural information available in the PDB for UniProt : Q9Y468 PDBe-KB .
PDB gallery
1oyx : CRYSTAL STRUCTURE OF 3-MBT REPEATS OF LETHAL (3) MALIGNANT BRAIN TUMOR (SELENO-MET) AT 1.85 ANGSTROM
1oz2 : CRYSTAL STRUCTURE OF 3-MBT REPEATS OF LETHAL (3) MALIGNANT BRAIN TUMOR (NATIVE-II) AT 1.55 ANGSTROM
1oz3 : Crystal Structure of 3-MBT repeats of lethal (3) malignant Brain Tumor (Native-I) at 1.85 angstrom
