Kielmeyera variabilis

Kielmeyera variabilis
Scientific classification
Kingdom:	Plantae
Clade:	Tracheophytes
Clade:	Angiosperms
Clade:	Eudicots
Clade:	Rosids
Order:	Malpighiales
Family:	Calophyllaceae
Genus:	Kielmeyera
Species:	K. variabilis
Binomial name
	Kielmeyera variabilis; Mart. et Zucc.

Kielmeyera variabilis (malva-do-campo or pau santo) is tree growing to a height of 3–6 meters, found in savannah regions of eastern and central Brazil (the Cerrado).^[1] K. variabilis is traditionally used in folk medicine to treat tropical diseases including schistosomiasis, leishmaniasis, malaria, as well as fungal and bacterial infections.^[2]

K. variabilis has been shown to contain three flavonols and a biflavone known to show antioxidant activity: quercitrin, quercetin-3-O-β-glucoside, quercetin-3-O-β-galactoside; and podocarpusflavone A (the biflavone).^[3]

In 2019 a new acylphoroglucinol isolated from the branches of the tree showed activity against Methicillin-resistant Staphylococcus aureus (MRSA).^[4]

Notes

^ Ken Fern (2020). "Kielmeyera variabilis". Tropical Plants Database. Retrieved May 4, 2020.
^ Alves TMA, Silva AF, Brandão M, Grandi TSM, Smânia EF, Smânia Jr A, Zani CL 2000. Biological screening of Brazilian medicinal plants. Mem Inst Oswaldo Cruz 95: 367-373.
^ Coqueiro, Aline; Regasini, Luis; Skrzek, Scheila; Queiroz, Marcos; Silva, Dulce; da Silva Bolzani, Vanderlan (2013). "Free Radical Scavenging Activity of Kielmeyera variabilis (Clusiaceae)". Molecules. 18 (2): 2376–2385. doi:10.3390/molecules18022376. ISSN 1420-3049. PMC 6270038. PMID 23429348.
^ Coqueiro, Aline; Choi, Young H.; Verpoorte, Robert; Gupta, Karthick B. S. S.; De Mieri, Maria; Hamburger, Matthias; Young, Maria C. M.; Stapleton, Paul; Gibbons, Simon; Bolzani, Vanderlan da S. (2016). "Antistaphylococcal Prenylated Acylphoroglucinol and Xanthones from Kielmeyera variabilis". Journal of Natural Products. 79 (3): 470–476. doi:10.1021/acs.jnatprod.5b00858. hdl:1887/3784787. ISSN 0163-3864. PMID 26900954.

References

Por, F.D. (2002). The Pantanal of Mato Grosso (Brazil): World's Largest Wetlands (Monographiae Biologicae). Springer. ISBN 0-7923-3481-7.
Raffauf, Robert F. (1996). Plant Alkaloids: A Guide to Their Discovery and Distribution. Food Products Press. ISBN 1-56022-860-1.

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[1] Ken Fern (2020). "Kielmeyera variabilis". Tropical Plants Database. Retrieved May 4, 2020.

[2] Alves TMA, Silva AF, Brandão M, Grandi TSM, Smânia EF, Smânia Jr A, Zani CL 2000. Biological screening of Brazilian medicinal plants. Mem Inst Oswaldo Cruz 95: 367-373.

[CoqueiroRegasini2013-3] Coqueiro, Aline; Regasini, Luis; Skrzek, Scheila; Queiroz, Marcos; Silva, Dulce; da Silva Bolzani, Vanderlan (2013). "Free Radical Scavenging Activity of Kielmeyera variabilis (Clusiaceae)". Molecules. 18 (2): 2376–2385. doi:10.3390/molecules18022376. ISSN 1420-3049. PMC 6270038. PMID 23429348.

[CoqueiroChoi2016-4] Coqueiro, Aline; Choi, Young H.; Verpoorte, Robert; Gupta, Karthick B. S. S.; De Mieri, Maria; Hamburger, Matthias; Young, Maria C. M.; Stapleton, Paul; Gibbons, Simon; Bolzani, Vanderlan da S. (2016). "Antistaphylococcal Prenylated Acylphoroglucinol and Xanthones from Kielmeyera variabilis". Journal of Natural Products. 79 (3): 470–476. doi:10.1021/acs.jnatprod.5b00858. hdl:1887/3784787. ISSN 0163-3864. PMID 26900954.

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