Karin Hoffmeister
Karin Hoffmeister is a Polish-born physician-scientist specializing in glycoscience, the study of sugars and carbohydrates on cell surfaces. She holds the Hauske Family Endowed Chair in Glycobiology at the Versiti Blood Research Institute.
Early life and education
[edit]Hoffmeister was born in Poland and obtained her MD at the University of Aachen in Germany.[1]
Career
[edit]Hoffmeister chose to study glycans because they are on the cell surface, where they are visible to the immune system, and they underlie the ABO blood groups which play key roles in blood transfusion and organ transplantation.[1] Her work has helped show how glycan patterns contribute to blood cell production,[2][3][4][5] cancer biology,[6] sickle cell anemia,[7] and other diseases.[8] She has described her goal as trying to "unravel the sugar-code".[9]
In 2003, Hoffmeister was first author on a Science paper testing a new technique to prevent chilled platelets from being cleared by macrophages, in hopes of extending the shelf life of platelets to ease inventory management constraints and reduce the chance of septic reactions.[10][11] The technique involved covering a sugar on the platelet surface with galactose.[12] Hoffmeister was promoted to Associate Professor at Harvard Medical School.[13]
In 2017, she joined Versiti Blood Research Institute in Milwaukee and established its glycomics center.[1] Her work on sialic acid has helped identify new therapeutic targets for treating immune thrombocytopenic purpura.[14][15]
She is principal investigator of the NHLBI career development consortium for excellence in glycoscience.[16]
Awards
[edit]2005 Pew Scholar[13]
References
[edit]- ^ a b c "Women of Distinction 2024: Karin Hoffmeister of Versiti Blood Research Institute". Milwaukee Magazine. 2024-11-08. Retrieved 2024-12-31.
- ^ Falet, Hervé; Rivadeneyra, Leonardo; Hoffmeister, Karin M. (2022-06-02). "Clinical impact of glycans in platelet and megakaryocyte biology" (PDF). Blood. 139 (22): 3255–3263. doi:10.1182/blood.2020009303. ISSN 0006-4971. PMC 9164739. PMID 35015813. Retrieved 2024-12-31.
- ^ Rivadeneyra, Leonardo; Falet, Hervé; Hoffmeister, Karin M. (2021). "Circulating platelet count and glycans". Current Opinion in Hematology. 28 (6): 431–437. doi:10.1097/MOH.0000000000000682. ISSN 1065-6251. PMC 8641398. PMID 34605444.
- ^ MM, Lee-Sundlov; SR, Stowell; KM, Hoffmeister (2020). "Multifaceted role of glycosylation in transfusion medicine, platelets, and red blood cells". Journal of Thrombosis and Haemostasis : JTH. 18 (7). J Thromb Haemost: 1535–1547. doi:10.1111/jth.14874. ISSN 1538-7836. PMC 7336546. PMID 32350996.
- ^ Giannini, Silvia; Lee-Sundlov, Melissa M.; Rivadeneyra, Leonardo (2020-01-17). "β4GALT1 controls β1 integrin function to govern thrombopoiesis and hematopoietic stem cell homeostasis" (PDF). Nature Communications. 11 (1): 356. doi:10.1038/s41467-019-14178-y. ISSN 2041-1723. PMC 6968998. PMID 31953383. Retrieved 2024-12-31.
- ^ Di Buduo, Christian A.; Giannini, Silvia (2021-04-15). "Increased B4GALT1 expression is associated with platelet surface galactosylation and thrombopoietin plasma levels in MPNs" (PDF). Blood. 137 (15): 2085–2089. doi:10.1182/blood.2020007265. ISSN 0006-4971. Retrieved 2024-12-31.
- ^ HE, Ashwood; C, Ashwood; AP, Schmidt; RL, Gundry; KM, Hoffmeister; WQ, Anani (2021). "Characterization and statistical modeling of glycosylation changes in sickle cell disease" (PDF). Blood Advances. 5 (5). Blood Adv: 1463–1473. doi:10.1182/bloodadvances.2020003376. ISSN 2473-9537. PMC 7948272. PMID 33666655. Retrieved 2024-12-31.
- ^ Sackstein, Robert; Hoffmeister, Karin M.; Stowell, Sean R.; Kinoshita, Taroh; Varki, Ajit; Freeze, Hudson H. (2022). "Glycans in Acquired Human Diseases". Essentials of Glycobiology. Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press. doi:10.1101/glycobiology.4e.46 (inactive 8 January 2025). ISBN 978-1-62182-421-3. PMID 35536944.
{{cite book}}: CS1 maint: DOI inactive as of January 2025 (link) - ^ "Notable Women in STEM: Dr. Karin Hoffmeister". BizTimes - Milwaukee Business News. 2023-03-28. Retrieved 2024-12-31.
- ^ Couzin-Frankel, Jennifer (2003-09-11). "Platelets Chilled to Order". www.science.org. Retrieved 2024-12-31.
- ^ "A cold-blooded solution". Harvard Gazette. 2003-09-18. Retrieved 2024-12-31.
- ^ "News In Brief". The Michigan Daily. 2003-09-11. Retrieved 2024-12-31.
- ^ a b "Karin M. Hoffmeister, M.D." The Pew Charitable Trusts. 2024-05-29. Retrieved 2024-12-31.
- ^ Li, June; Wal, van der; E., Dianne (2015-07-17). "Desialylation is a mechanism of Fc-independent platelet clearance and a therapeutic target in immune thrombocytopenia" (PDF). Nature Communications. 6 (1). Nature Publishing Group: 1–16. doi:10.1038/ncomms8737. ISSN 2041-1723. Retrieved 2024-12-31.
- ^ Hoffmeister, Karin M. (2020-06-18). "The never-ending enigma of immune thrombocytopenia" (PDF). Blood. 135 (25): 2207–2209. doi:10.1182/blood.2020005555. ISSN 0006-4971. PMID 32556133. Retrieved 2024-12-31.
- ^ "NHLBI Celebrates Women Scientists:Dr. Karin Hoffmeister, M.D." NHLBI, NIH. 2019-03-13. Retrieved 2024-12-31.