HDAC10

HDAC10
Identifiers
Aliases	HDAC10, HD10, histone deacetylase 10
External IDs	OMIM: 608544; MGI: 2158340; HomoloGene: 23749; GeneCards: HDAC10; OMA:HDAC10 - orthologs
Gene location (Human) Chr. Chromosome 22 (human) Band 22q13.33 Start 50,245,183 bp End 50,251,405 bp
Gene location (Mouse) Chr. Chromosome 15 (mouse) Band 15|15 E3 Start 89,007,510 bp End 89,012,903 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte right uterine tube right hemisphere of cerebellum anterior pituitary mucosa of transverse colon spleen right ovary canal of the cervix right frontal lobe left ovary Top expressed in granulocyte right kidney muscle of thigh esophagus lip proximal tubule neural layer of retina lacrimal gland mesenteric lymph nodes neural tube More reference expression data BioGPS n/a
Gene ontology Molecular function NAD-dependent histone deacetylase activity (H3-K14 specific) protein deacetylase activity histone deacetylase binding protein binding enzyme binding hydrolase activity histone deacetylase activity zinc ion binding deacetylase activity acetylputrescine deacetylase activity acetylspermidine deacetylase activity metal ion binding Cellular component cytoplasm histone deacetylase complex nucleoplasm nucleus Biological process histone H3 deacetylation regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II transcription, DNA-templated protein deacetylation oligodendrocyte development negative regulation of transcription, DNA-templated histone deacetylation chromatin organization macroautophagy positive regulation of mismatch repair peptidyl-lysine deacetylation homologous recombination polyamine deacetylation spermidine deacetylation DNA repair DNA recombination autophagy cellular response to DNA damage stimulus Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 83933 170787 Ensembl ENSG00000100429 ENSMUSG00000062906 UniProt Q969S8 Q08AP5 Q6P3E7 RefSeq (mRNA) NM_032019 NM_001159286 NM_199198 RefSeq (protein) NP_001152758 NP_114408 NP_954668 Location (UCSC) Chr 22: 50.25 – 50.25 Mb Chr 15: 89.01 – 89.01 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Histone deacetylase 10 is an enzyme that in humans is encoded by the HDAC10 gene. HDAC10 is a class IIb HDAC. It specifically has selectivity for long, slender polyamines like N8-acetylspermidine.

Acetylation of histone core particles modulates chromatin structure and gene expression. The opposing enzymatic activities of histone acetyltransferases and histone deacetylases, such as HDAC10, determine the acetylation status of histone tails (Kao et al., 2002).[supplied by OMIM]

Interactions

HDAC10 has been shown to interact with Histone deacetylase 2 and Nuclear receptor co-repressor 2.

See also

• Histone deacetylase

Further reading

• Bonaldo MF, Lennon G, Soares MB (September 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, et al. (December 1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–495. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.
• Fischer DD, Cai R, Bhatia U, Asselbergs FA, Song C, Terry R, et al. (February 2002). "Isolation and characterization of a novel class II histone deacetylase, HDAC10". The Journal of Biological Chemistry. 277 (8): 6656–6666. doi:10.1074/jbc.M108055200. PMID 11739383.
• Tong JJ, Liu J, Bertos NR, Yang XJ (March 2002). "Identification of HDAC10, a novel class II human histone deacetylase containing a leucine-rich domain". Nucleic Acids Research. 30 (5): 1114–1123. doi:10.1093/nar/30.5.1114. PMC 101247. PMID 11861901.
• Rodriguez M, Yu X, Chen J, Songyang Z (December 2003). "Phosphopeptide binding specificities of BRCA1 COOH-terminal (BRCT) domains". The Journal of Biological Chemistry. 278 (52): 52914–52918. doi:10.1074/jbc.C300407200. PMID 14578343.
• Hillman RT, Green RE, Brenner SE (2005). "An unappreciated role for RNA surveillance". Genome Biology. 5 (2): R8. doi:10.1186/gb-2004-5-2-r8. PMC 395752. PMID 14759258.
• Osada H, Tatematsu Y, Saito H, Yatabe Y, Mitsudomi T, Takahashi T (October 2004). "Reduced expression of class II histone deacetylase genes is associated with poor prognosis in lung cancer patients". International Journal of Cancer. 112 (1): 26–32. doi:10.1002/ijc.20395. PMID 15305372. S2CID 23452893.
• Collins JE, Wright CL, Edwards CA, Davis MP, Grinham JA, Cole CG, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biology. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.

External links

• HDAC10+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.