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Emily Bernstein

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Emily Bernstein
Alma materState University of New York at Stony Brook
Scientific career
InstitutionsMount Sinai College of Medicine
ThesisDicer, a novel RNase III, is required for RNA interference and development (2003)
Doctoral advisorGregory Hannon

Emily Bernstein is a professor at Mount Sinai School of Medicine known for her research on RNA interference, epigenetics, and cancer, especially melanoma.

Education and career

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Bernstein received her B.S. from McGill University in 1998 and earned a Ph.D. from Stony Brook University in 2003.[1] Following her Ph.D. she was a postdoctoral researcher at Rockefeller University where she worked with David Allis.[2] In 2008 she moved to Mount Sinai School of Medicine where, as of 2022, she is a professor in the department of oncology and dermatology.[3]

Research

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Bernstein is known for her research on RNA interference, epigenetics, and cell development. Her early research examined the enzyme Dicer, its role in cell development in mice,[4] and RNA interference.[5] While a postdoctoral researcher she examined linkages between non-coding RNA and chromatin[6][7] and DNA methylation.[8] Subsequently, she has worked on histones,[9][10] gene silencing,[11] and tumor cell development.[12][13] In 2022 her team discovered alterations to a gene which can lead to melanoma.[14][15]

Selected publications

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  • Bernstein, Emily; Caudy, Amy A.; Hammond, Scott M.; Hannon, Gregory J. (2001). "Role for a bidentate ribonuclease in the initiation step of RNA interference". Nature. 409 (6818): 363–366. doi:10.1038/35053110. ISSN 0028-0836. PMID 11201747. S2CID 4371481.
  • Hammond, Scott M.; Bernstein, Emily; Beach, David; Hannon, Gregory J. (2000). "An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells". Nature. 404 (6775): 293–296. Bibcode:2000Natur.404..293H. doi:10.1038/35005107. ISSN 0028-0836. PMID 10749213. S2CID 9091863.
  • Goldberg, Aaron D.; Allis, C. David; Bernstein, Emily (2007-02-23). "Epigenetics: A Landscape Takes Shape". Cell. 128 (4): 635–638. doi:10.1016/j.cell.2007.02.006. ISSN 0092-8674. PMID 17320500. S2CID 16604496.
  • Bernstein, Emily; Kim, Sang Yong; Carmell, Michelle A; Murchison, Elizabeth P; Alcorn, Heather; Li, Mamie Z; Mills, Alea A; Elledge, Stephen J; Anderson, Kathryn V; Hannon, Gregory J (2003-11-01). "Dicer is essential for mouse development". Nature Genetics. 35 (3): 215–217. doi:10.1038/ng1253. ISSN 1061-4036. PMID 14528307. S2CID 972721.

Awards and honors

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In 2014 Bernstein received a young investigators award from the Pershing Square Foundation.[16]

References

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  1. ^ "Speakers". 2022-05-15. Archived from the original on 15 May 2022. Retrieved 2022-05-15.
  2. ^ "Investigator | Bernstein Laboratory". Bernstein Laboratory |. 2015-04-16. Retrieved 2022-05-15.
  3. ^ "Emily Bernstein | Mount Sinai - New York". Mount Sinai Health System. Retrieved 2022-05-15.
  4. ^ Bernstein, Emily; Kim, Sang Yong; Carmell, Michelle A; Murchison, Elizabeth P; Alcorn, Heather; Li, Mamie Z; Mills, Alea A; Elledge, Stephen J; Anderson, Kathryn V; Hannon, Gregory J (2003-11-01). "Dicer is essential for mouse development". Nature Genetics. 35 (3): 215–217. doi:10.1038/ng1253. ISSN 1061-4036. PMID 14528307. S2CID 972721.
  5. ^ Bernstein, Emily; Caudy, Amy A.; Hammond, Scott M.; Hannon, Gregory J. (2001). "Role for a bidentate ribonuclease in the initiation step of RNA interference". Nature. 409 (6818): 363–366. doi:10.1038/35053110. ISSN 0028-0836. PMID 11201747. S2CID 4371481.
  6. ^ Bernstein, Emily; Allis, C. David (2005-07-15). "RNA meets chromatin". Genes & Development. 19 (14): 1635–1655. doi:10.1101/gad.1324305. ISSN 0890-9369. PMID 16024654.
  7. ^ Bernstein, Emily; Duncan, Elizabeth M.; Masui, Osamu; Gil, Jesus; Heard, Edith; Allis, C. David (2006). "Mouse Polycomb Proteins Bind Differentially to Methylated Histone H3 and RNA and Are Enriched in Facultative Heterochromatin". Molecular and Cellular Biology. 26 (7): 2560–2569. doi:10.1128/MCB.26.7.2560-2569.2006. ISSN 0270-7306. PMC 1430336. PMID 16537902.
  8. ^ Ooi, Steen K. T.; Qiu, Chen; Bernstein, Emily; Li, Keqin; Jia, Da; Yang, Zhe; Erdjument-Bromage, Hediye; Tempst, Paul; Lin, Shau-Ping; Allis, C. David; Cheng, Xiaodong (2007). "DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA". Nature. 448 (7154): 714–717. Bibcode:2007Natur.448..714O. doi:10.1038/nature05987. ISSN 0028-0836. PMC 2650820. PMID 17687327.
  9. ^ Gaspar-Maia, Alexandre; Qadeer, Zulekha A.; Hasson, Dan; Ratnakumar, Kajan; Adrian Leu, N.; Leroy, Gary; Liu, Shichong; Costanzi, Carl; Valle-Garcia, David; Schaniel, Christoph; Lemischka, Ihor (2013-06-26). "MacroH2A histone variants act as a barrier upon reprogramming towards pluripotency". Nature Communications. 4 (1): 1565. Bibcode:2013NatCo...4.1565G. doi:10.1038/ncomms2582. ISSN 2041-1723. PMC 4055026. PMID 23463008.
  10. ^ Vardabasso, Chiara; Hasson, Dan; Ratnakumar, Kajan; Chung, Chi-Yeh; Duarte, Luis F.; Bernstein, Emily (2014). "Histone variants: emerging players in cancer biology". Cellular and Molecular Life Sciences. 71 (3): 379–404. doi:10.1007/s00018-013-1343-z. ISSN 1420-682X. PMC 4025945. PMID 23652611.
  11. ^ Chicas, Agustin; Kapoor, Avnish; Wang, Xiaowo; Aksoy, Ozlem; Evertts, Adam G.; Zhang, Michael Q.; Garcia, Benjamin A.; Bernstein, Emily; Lowe, Scott W. (2012-06-05). "H3K4 demethylation by Jarid1a and Jarid1b contributes to retinoblastoma-mediated gene silencing during cellular senescence". Proceedings of the National Academy of Sciences. 109 (23): 8971–8976. Bibcode:2012PNAS..109.8971C. doi:10.1073/pnas.1119836109. ISSN 0027-8424. PMC 3384172. PMID 22615382.
  12. ^ Sosa, Maria Soledad; Parikh, Falguni; Maia, Alexandre Gaspar; Estrada, Yeriel; Bosch, Almudena; Bragado, Paloma; Ekpin, Esther; George, Ajish; Zheng, Yang; Lam, Hung-Ming; Morrissey, Colm (2015). "NR2F1 controls tumour cell dormancy via SOX9- and RARβ-driven quiescence programmes". Nature Communications. 6 (1): 6170. Bibcode:2015NatCo...6.6170S. doi:10.1038/ncomms7170. ISSN 2041-1723. PMC 4313575. PMID 25636082.
  13. ^ Strub, Thomas; Ghiraldini, Flavia G.; Carcamo, Saul; Li, Man; Wroblewska, Aleksandra; Singh, Rajendra; Goldberg, Matthew S.; Hasson, Dan; Wang, Zichen; Gallagher, Stuart J.; Hersey, Peter (2018). "SIRT6 haploinsufficiency induces BRAFV600E melanoma cell resistance to MAPK inhibitors via IGF signalling". Nature Communications. 9 (1): 3440. Bibcode:2018NatCo...9.3440S. doi:10.1038/s41467-018-05966-z. ISSN 2041-1723. PMC 6109055. PMID 30143629.
  14. ^ "Scientists discover gene mutation that signals aggressive melanoma". ScienceDaily. April 6, 2022. Retrieved 2022-05-15.
  15. ^ Carcamo, Saul; Nguyen, Christie B.; Grossi, Elena; Filipescu, Dan; Alpsoy, Aktan; Dhiman, Alisha; Sun, Dan; Narang, Sonali; Imig, Jochen; Martin, Tiphaine C.; Parsons, Ramon (2022-04-05). "Altered BAF occupancy and transcription factor dynamics in PBAF-deficient melanoma". Cell Reports. 39 (1): 110637. doi:10.1016/j.celrep.2022.110637. ISSN 2211-1247. PMC 9013128. PMID 35385731.
  16. ^ Benson, Barbara (May 5, 2014). "Wall Street funds cancer-research up-and-comers". Crain's New York Business; New York. Vol. 30, no. 18. p. 22 – via ProQuest.
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