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Dual specificity phosphatase 8

From Wikipedia, the free encyclopedia
DUSP8
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesDUSP8, C11orf81, HB5, HVH-5, HVH8, dual specificity phosphatase 8
External IDsOMIM: 602038; MGI: 106626; HomoloGene: 31239; GeneCards: DUSP8; OMA:DUSP8 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004420

NM_008748

RefSeq (protein)

NP_004411

NP_032774

Location (UCSC)Chr 11: 1.55 – 1.57 MbChr 7: 141.63 – 141.65 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Dual specificity phosphatase 8 is a protein that in humans is encoded by the DUSP8 gene. [5]

Function

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The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates SAPK/JNK and p38, is expressed predominantly in the adult brain, heart, and skeletal muscle, is localized in the cytoplasm, and is induced by nerve growth factor and insulin. An intronless pseudogene for DUSP8 is present on chromosome 10q11.2.

References

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  1. ^ a b c ENSG00000273793, ENSG00000278165 GRCh38: Ensembl release 89: ENSG00000184545, ENSG00000273793, ENSG00000278165Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000037887Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Dual specificity phosphatase 8". Retrieved 2017-09-08.

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.