CRB3

CRB3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	5I7Z
Identifiers
Aliases	CRB3, crumbs 3, cell polarity complex component, crumbs cell polarity complex component 3
External IDs	OMIM: 609737; MGI: 2670904; HomoloGene: 138188; GeneCards: CRB3; OMA:CRB3 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	6,467,221 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	57,372,918 bp
RNA expression pattern
	Top expressed in
	mucosa of pharynx; ; mucosa of transverse colon; ; vena cava; ; nasal epithelium; ; skin of arm; ; body of pancreas; ; parotid gland; ; body of tongue; ; pylorus; ; skin of leg;
	Top expressed in
	yolk sac; ; secondary oocyte; ; zygote; ; duodenum; ; right kidney; ; stomach; ; morula; ; morula; ; pyloric antrum; ; mucous cell of stomach;
	More reference expression data
	n/a
Gene ontology
Molecular function	SH3 domain binding; protein binding; protein domain specific binding;
Cellular component	integral component of membrane; cell junction; plasma membrane; apical part of cell; extracellular exosome; apical plasma membrane; membrane; bicellular tight junction; protein-containing complex;
Biological process	protein localization to plasma membrane; bicellular tight junction assembly;
	Sources:Amigo / QuickGO
Orthologs
	92359
	224912
	ENSG00000130545
	ENSMUSG00000044279
	Q9BUF7
	Q8QZT4
	NM_139161; NM_174881; NM_174882
	NM_177638; NM_001347408; NM_001359813; NM_001359814
	NP_631900; NP_777377; NP_777378
	NP_001334337; NP_808306; NP_001346742; NP_001346743
	Wikidata
View/Edit Human	View/Edit Mouse

Crumbs protein homolog 3 is a protein that in humans is encoded by the CRB3 gene.^[5]

Function

This gene encodes a member of the Crumbs family of proteins. This protein may play a role in epithelial cell polarity and is associated with tight junctions at the apical surface of epithelial cells. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000130545 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000044279 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: CRB3 crumbs homolog 3 (Drosophila)".

External links

Human CRB3 genome location and CRB3 gene details page in the UCSC Genome Browser.

Lemmers C, Médina E, Delgrossi MH, Michel D, Arsanto JP, Le Bivic A (Jul 2002). "hINADl/PATJ, a homolog of discs lost, interacts with crumbs and localizes to tight junctions in human epithelial cells". The Journal of Biological Chemistry. 277 (28): 25408–15. doi:10.1074/jbc.M202196200. PMID 11964389.
Makarova O, Roh MH, Liu CJ, Laurinec S, Margolis B (Jan 2003). "Mammalian Crumbs3 is a small transmembrane protein linked to protein associated with Lin-7 (Pals1)". Gene. 302 (1–2): 21–9. doi:10.1016/S0378111902010843. PMID 12527193.
Roh MH, Fan S, Liu CJ, Margolis B (Jul 2003). "The Crumbs3-Pals1 complex participates in the establishment of polarity in mammalian epithelial cells". Journal of Cell Science. 116 (Pt 14): 2895–906. doi:10.1242/jcs.00500. PMID 12771187.
Lemmers C, Michel D, Lane-Guermonprez L, Delgrossi MH, Médina E, Arsanto JP, Le Bivic A (Mar 2004). "CRB3 binds directly to Par6 and regulates the morphogenesis of the tight junctions in mammalian epithelial cells". Molecular Biology of the Cell. 15 (3): 1324–33. doi:10.1091/mbc.E03-04-0235. PMC 363137. PMID 14718572.
Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW (Jun 2004). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nature Biotechnology. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
Fogg VC, Liu CJ, Margolis B (Jul 2005). "Multiple regions of Crumbs3 are required for tight junction formation in MCF10A cells". Journal of Cell Science. 118 (Pt 13): 2859–69. doi:10.1242/jcs.02412. PMID 15976445.
Fan S, Fogg V, Wang Q, Chen XW, Liu CJ, Margolis B (Jul 2007). "A novel Crumbs3 isoform regulates cell division and ciliogenesis via importin beta interactions". The Journal of Cell Biology. 178 (3): 387–98. doi:10.1083/jcb.200609096. PMC 2064851. PMID 17646395.

This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000130545 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000044279 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: CRB3 crumbs homolog 3 (Drosophila)".

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Function

References

External links

Further reading