Aquaporin-9

AQP9
Identifiers
Aliases	AQP9, AQP-9, HsT17287, SSC1, T17287, aquaporin 9
External IDs	OMIM: 602914; MGI: 1891066; HomoloGene: 41405; GeneCards: AQP9; OMA:AQP9 - orthologs
Gene location (Human) Chr. Chromosome 15 (human) Band 15q21.3 Start 58,138,169 bp End 58,185,911 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9|9 D Start 71,017,941 bp End 71,075,964 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in blood monocyte right lobe of liver periodontal fiber granulocyte caput epididymis germinal epithelium corpus epididymis bone marrow right lung Top expressed in left lobe of liver spermatocyte granulocyte spermatid zygote secondary oocyte seminiferous tubule primary oocyte blood blastocyst More reference expression data BioGPS n/a
Gene ontology Molecular function porin activity carboxylic acid transmembrane transporter activity polyol transmembrane transporter activity water transmembrane transporter activity purine nucleobase transmembrane transporter activity pyrimidine nucleobase transmembrane transporter activity amine transmembrane transporter activity water channel activity urea channel activity glycerol channel activity channel activity urea transmembrane transporter activity Cellular component integral component of membrane intracellular membrane-bounded organelle membrane plasma membrane integral component of plasma membrane basolateral plasma membrane Biological process canalicular bile acid transport excretion water transport amine transport response to organic substance water homeostasis response to osmotic stress polyol transport carboxylic acid transport immune response pyrimidine nucleobase transport response to mercury ion glycerol transport cellular response to cAMP purine nucleobase transport carboxylic acid transmembrane transport purine nucleobase transmembrane transport pyrimidine-containing compound transmembrane transport transmembrane transport urea transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 366 64008 Ensembl ENSG00000103569 ENSMUSG00000032204 UniProt O43315 Q9JJJ3 RefSeq (mRNA) NM_020980 NM_001320635 NM_001320636 NM_001271843 NM_022026 RefSeq (protein) NP_001307564 NP_001307565 NP_066190 NP_001258772 NP_071309 Location (UCSC) Chr 15: 58.14 – 58.19 Mb Chr 9: 71.02 – 71.08 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Aquaporin-9 (AQP-9) is a protein that in humans is encoded by the AQP9 gene.

The aquaporins/major intrinsic protein are a family of water-selective membrane channels. Aquaporin-9 has greater sequence similarity with AQP3 and AQP7 and they may be a subfamily. Aquaporin-9 allows passage of a wide variety of noncharged solutes. AQP-9 stimulates urea transport and osmotic water permeability; there are contradicting reports about its role in providing glycerol permeability. Aquaporin-9 may also have some role in specialized leukocyte functions such as immunological response and bactericidal activity.

Further reading

• Ishibashi K, Kuwahara M, Gu Y, et al. (1998). "Cloning and functional expression of a new aquaporin (AQP9) abundantly expressed in the peripheral leukocytes permeable to water and urea, but not to glycerol". Biochem. Biophys. Res. Commun. 244 (1): 268–74. doi:10.1006/bbrc.1998.8252. PMID 9514918.
• Tsukaguchi H, Shayakul C, Berger UV, et al. (1998). "Molecular characterization of a broad selectivity neutral solute channel". J. Biol. Chem. 273 (38): 24737–43. doi:10.1074/jbc.273.38.24737. PMID 9733774.
• Tsukaguchi H, Weremowicz S, Morton CC, Hediger MA (1999). "Functional and molecular characterization of the human neutral solute channel aquaporin-9". Am. J. Physiol. 277 (5 Pt 2): F685–96. doi:10.1152/ajprenal.1999.277.5.F685. PMID 10564231. S2CID 4516233.
• Pastor-Soler N, Bagnis C, Sabolic I, et al. (2001). "Aquaporin 9 expression along the male reproductive tract". Biol. Reprod. 65 (2): 384–93. doi:10.1095/biolreprod65.2.384. PMID 11466204.
• Damiano A, Zotta E, Goldstein J, et al. (2001). "Water channel proteins AQP3 and AQP9 are present in syncytiotrophoblast of human term placenta". Placenta. 22 (8–9): 776–81. doi:10.1053/plac.2001.0717. PMID 11597198.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Okada S, Misaka T, Matsumoto I, et al. (2003). "Aquaporin-9 is expressed in a mucus-secreting goblet cell subset in the small intestine". FEBS Lett. 540 (1–3): 157–62. doi:10.1016/S0014-5793(03)00256-4. PMID 12681500. S2CID 20184558.
• Bhattacharjee H, Carbrey J, Rosen BP, Mukhopadhyay R (2004). "Drug uptake and pharmacological modulation of drug sensitivity in leukemia by AQP9". Biochem. Biophys. Res. Commun. 322 (3): 836–41. doi:10.1016/j.bbrc.2004.08.002. PMID 15336539.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wang S, Chen J, Beall M, et al. (2005). "Expression of aquaporin 9 in human chorioamniotic membranes and placenta". Am. J. Obstet. Gynecol. 191 (6): 2160–7. doi:10.1016/j.ajog.2004.05.089. PMID 15592307.
• Damiano AE, Zotta E, Ibarra C (2006). "Functional and molecular expression of AQP9 channel and UT-A transporter in normal and preeclamptic human placentas". Placenta. 27 (11–12): 1073–81. doi:10.1016/j.placenta.2005.11.014. PMID 16480766.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
• Loitto VM, Huang C, Sigal YJ, Jacobson K (2007). "Filopodia are induced by aquaporin-9 expression". Exp. Cell Res. 313 (7): 1295–306. doi:10.1016/j.yexcr.2007.01.023. PMID 17346701.
• Warth A, Mittelbronn M, Hülper P, et al. (2007). "Expression of the water channel protein aquaporin-9 in malignant brain tumors". Appl. Immunohistochem. Mol. Morphol. 15 (2): 193–8. doi:10.1097/01.pai.0000213110.05108.e9. PMID 17525633. S2CID 24070875.

External links

• AQP9+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• Human AQP9 genome location and AQP9 gene details page in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.