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All-trans-retinol 13,14-reductase

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All-trans-retinol 13,14-reductase
Identifiers
Aliases(13,14)-all-trans-retinol saturaseRetSatall-trans-13,14-dihydroretinol:acceptor 13,14-oxidoreductaseall-trans-retinol:all-trans-13,14-dihydroretinol saturaseretinol saturase
External IDsGeneCards: [1]; OMA:- orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

n/a

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RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human
all-trans-retinol 13,14-reductase
Identifiers
EC no.1.3.99.23
CAS no.418767-56-3
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins

In enzymology, an all-trans-retinol 13,14-reductase (EC 1.3.99.23) is an enzyme, encoded by the RETSAT gene,[1][2][3] that catalyzes the chemical reaction

all-trans-13,14-dihydroretinol + acceptor all-trans-retinol + reduced acceptor

Thus, the two substrates of this enzyme are all-trans-13,14-dihydroretinol and acceptor, whereas its two products are all-trans-retinol and reduced acceptor. Under physiological conditions the reaction proceeds in the opposite direction catalyzing the saturation of the 13-14 double bond of all-trans-retinol.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with other acceptors. The systematic name of this enzyme class is all-trans-13,14-dihydroretinol:acceptor 13,14-oxidoreductase. Other names in common use include retinol saturase, RetSat, (13,14)-all-trans-retinol saturase, and all-trans-retinol:all-trans-13,14-dihydroretinol saturase.

The gene has also been called PPAR-alpha-regulated and starvation-induced gene protein.[4]

References

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  1. ^ Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A (Oct 2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
  2. ^ Moise AR, Kuksa V, Imanishi Y, Palczewski K (Nov 2004). "Identification of All-trans-Retinol:All-trans-13,14-dihydroretinol Saturase*". J Biol Chem. 279 (48): 50230–42. doi:10.1074/jbc.M409130200. PMC 2665716. PMID 15358783.
  3. ^ "Entrez Gene: RETSAT retinol saturase (all-trans-retinol 13,14-reductase)".
  4. ^ "RETSAT - All-trans-retinol 13,14-reductase precursor - Homo sapiens (Human) - RETSAT gene & protein". www.uniprot.org. Retrieved 2017-11-05.

Further reading

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