Adolf Stachel

Adolf Stachel
Born	28 February 1913 Augsburg, Germany
Died	1971 Frankfurt am Main, Germany
Occupation	Chemist
Employer	Cassella

Adolf Stachel (born 28 February 1913 in Augsburg, died 1971 in Frankfurt am Main) was a German chemist, researcher and inventor, who worked as a researcher at the chemical and pharmaceutical company Cassella (now Sanofi) in Frankfurt-Fechenheim for much of his career.

He held a doctoral degree in chemistry (Doktoringenieur) from the Technische Hochschule München. Early in his career, he was a mentee and collaborator of the Nobel Prize-winning chemist Hans Fischer, who was his doctoral supervisor. He later became a researcher at Cassella. His patents were related to basically substituted heterocyclic compounds, e.g. 2,3-benzotriazine-4(3H)-one derivatives (coumarin), and basically substituted 1H,3H)-quinazoline-2-thion-4-one derivatives, having excellent coronary dilator properties. Patentee was Cassella. When working at Cassella, he was a close collaborator of Armin K.W. Kutzsche. Together with Werner Zerweck they developed Nu-nu-dibenzylsulfamyl benzoic acid, US patent 2805250 A, in the early 1950s. Other frequent collaborators were Rudi Beyerle, Rolf-Eberhard Nitz and Klaus Resag.

He was married to Ingeburg Lydia Katharina Rodenhausen (1923-2008).

Selected publications

• Stachel A (1939), Über Dimethoxy-dipyrromethene und Dihalogendipyrromethene und ihre Umsetzungen, doctoral dissertation, Technische Hochschule München, 23 February 1939, 31 pages.
• Fischer H, Stachel A (1939), "Über Dimethoxy-dipyrromethene und Dihalogen-dipyrromethene und ihre Umsetzungen," Hoppe-Seyler's Zeitschrift für physiologische Chemie (= Biological Chemistry), Volume 258, Issue 2–3, pp. 121–136, doi: 10.1515/bchm2.1939.258.2-3.121. Based on the above dissertation.
• Stachel A, Kutzsche A, Zerweck W (1957). Nu-nu-dibenzylsulfamyl benzoic acid. US Patent US 2805250 A.
• Beyerle R, Nitz RE, Resag K, Stachel A (1971). Pharmacologically-active trimethoxybenzoxyalkyl-piperazino(1')compounds. US Patent US 3594384 A.
• Stachel A, Nitz RE (1966). Method of increasing sodium chloride excretion. US Patent US 3250676 A.
• Stachel A, Nitz RE, Resag K, Kreiskott H (1968). Theophylline derivatives. US Patent US 3399195 A.
• Beyerle R, Stachel A, Nitz RE, Resag K (1970). Process for the production of coumarin derivatives. US Patent US 3541097 A.
• Beyerle R, Nitz RE, Resag K, Schraven E, Stachel A (1972). 3-({60 -substituted amino-{62 -alkoxybenzoxy-propyl)-6,7-or-6,7,8-alkoxy-1,2,3-benzotriazine-4(3h)-ones. US Patent US 3706739 A.
• Stachel A, Schraven E, Nitz RE, Resag K, Beyerle R (1973). 3-(alpha-substituted amino-beta-alkoxybenzoxypropyl)-6,7-or 6,7,8-alkoxy-1,2,3-benzotriazine-4(3h)-ones. US Patent US 3751413 A.
• Beyerle R, Stachel A (1973). Basically substituted 2,4-(1h,3h)-quinazolindione derivatives. US Patent US 3718648 A.
• Stachel A, Beyerle R, Kunze W, Nitz RE, Scholtholt J (1975). Basically substituted 1(2H)-phthalazinone derivatives. US Patent US 3894015 A.
• Beyerle R, Stachel A (1976). Piperazino substituted coumarin derivatives. US Patent US 3959281 A.