2,4-dienoyl-CoA reductase 1

DECR1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1W6U, 1W73, 1W8D
Identifiers
Aliases	DECR1, DECR, NADPH, SDR18C1, 2,4-dienoyl-CoA reductase 1, mitochondrial, 2,4-dienoyl-CoA reductase 1
External IDs	OMIM: 222745; MGI: 1914710; HomoloGene: 68178; GeneCards: DECR1; OMA:DECR1 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	90,053,633 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	15,945,507 bp
RNA expression pattern
	Top expressed in
	myocardium of left ventricle; ; right ventricle; ; right adrenal gland; ; right adrenal cortex; ; right lobe of liver; ; apex of heart; ; left adrenal gland; ; right auricle; ; left adrenal cortex; ; mucosa of transverse colon;
	Top expressed in
	right ventricle; ; myocardium of ventricle; ; interventricular septum; ; brown adipose tissue; ; cardiac muscles; ; cardiac muscle tissue of left ventricle; ; left lobe of liver; ; intercostal muscle; ; tunica adventitia of aorta; ; thoracic diaphragm;
	More reference expression data
	n/a
Gene ontology
Molecular function	oxidoreductase activity, acting on NAD(P)H; oxidoreductase activity; 2,4-dienoyl-CoA reductase (NADPH) activity; NADPH binding;
Cellular component	mitochondrial matrix; extracellular exosome; mitochondrion; nucleus; nucleoplasm; cytosol;
Biological process	fatty acid beta-oxidation; protein homotetramerization; fatty acid metabolic process; lipid metabolism; positive regulation of cold-induced thermogenesis;
	Sources:Amigo / QuickGO
Orthologs
	1666
	67460
	ENSG00000104325
	ENSMUSG00000028223
	Q16698
	Q9CQ62
	NM_001359; NM_001330575
	NM_026172
	NP_001317504; NP_001350
	NP_080448
	Wikidata
View/Edit Human	View/Edit Mouse

2,4-dienoyl-CoA reductase 1 is a protein that in humans is encoded by the DECR1 gene. ^[5]

Function

This gene encodes an accessory enzyme which participates in the beta-oxidation and metabolism of unsaturated fatty enoyl-CoA esters.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000104325 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028223 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: 2,4-dienoyl-CoA reductase 1". Retrieved 2017-09-12.

Alphey MS, Yu W, Byres E, Li D, Hunter WN (2005). "Structure and reactivity of human mitochondrial 2,4-dienoyl-CoA reductase: enzyme-ligand interactions in a distinctive short-chain reductase active site". J. Biol. Chem. 280 (4): 3068–77. doi:10.1074/jbc.M411069200. PMID 15531764.
Yu W, Chu X, Chen G, Li D (2005). "Studies of human mitochondrial 2,4-dienoyl-CoA reductase". Arch. Biochem. Biophys. 434 (1): 195–200. doi:10.1016/j.abb.2004.10.018. PMID 15629123.
Rosenzweig SD (2008). "Inflammatory manifestations in chronic granulomatous disease (CGD)". J. Clin. Immunol. 28 (Suppl 1): S67–72. doi:10.1007/s10875-007-9160-5. PMID 18193341. S2CID 5965278.
Kardon T, Senesi S, Marcolongo P, Legeza B, Bánhegyi G, Mandl J, Fulceri R, Benedetti A (2008). "Maintenance of luminal NADPH in the endoplasmic reticulum promotes the survival of human neutrophil granulocytes". FEBS Lett. 582 (13): 1809–15. doi:10.1016/j.febslet.2008.04.045. PMID 18472006. S2CID 41166916.
Mizuta I, Tsunoda T, Satake W, Nakabayashi Y, Watanabe M, Takeda A, Hasegawa K, Nakashima K, Yamamoto M, Hattori N, Murata M, Toda T (2008). "Calbindin 1, fibroblast growth factor 20, and alpha-synuclein in sporadic Parkinson's disease". Hum. Genet. 124 (1): 89–94. doi:10.1007/s00439-008-0525-5. PMID 18568448. S2CID 20604147.
Moe KT, Woon FP, De Silva DA, Wong P, Koh TH, Kingwell B, Chin-Dusting J, Wong MC (2008). "Association of acute ischemic stroke with the MTHFR C677T polymorphism but not with NOS3 gene polymorphisms in a Singapore population". Eur. J. Neurol. 15 (12): 1309–14. doi:10.1111/j.1468-1331.2008.02308.x. PMID 19049547. S2CID 10457617.
Hosgood HD, Zhang L, Shen M, Berndt SI, Vermeulen R, Li G, Yin S, Yeager M, Yuenger J, Rothman N, Chanock S, Smith M, Lan Q (2009). "Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity". Occup Environ Med. 66 (12): 848–53. doi:10.1136/oem.2008.044024. PMC 2928224. PMID 19773279.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ (2010). "Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression". PLOS ONE. 5 (9): e12862. Bibcode:2010PLoSO...512862H. doi:10.1371/journal.pone.0012862. PMC 2943476. PMID 20877624.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 8 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000104325 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028223 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: 2,4-dienoyl-CoA reductase 1". Retrieved 2017-09-12.

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2,4-dienoyl-CoA reductase 1

Function

See also

References

Further reading