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WIPF2

From Wikipedia, the free encyclopedia
WIPF2
Identifiers
AliasesWIPF2, WICH, WIRE, WAS/WASL interacting protein family member 2
External IDsOMIM: 609692; MGI: 1924462; HomoloGene: 15777; GeneCards: WIPF2; OMA:WIPF2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_133264

NM_197940

RefSeq (protein)

NP_573571

NP_922922

Location (UCSC)Chr 17: 40.22 – 40.28 MbChr 11: 98.75 – 98.8 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

WAS/WASL-interacting protein family member 2 is a protein that in humans is encoded by the WIPF2 gene.[5][6][7]

This gene encodes a WASP interacting protein (WIP)-related protein. It has been shown that this protein has a role in the WASP-mediated organization of the actin cytoskeleton and that this protein is a potential link between the activated platelet-derived growth factor receptor and the actin polymerization machinery.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000171475Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038013Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Aspenstrom P (Sep 2002). "The WASP-binding protein WIRE has a role in the regulation of the actin filament system downstream of the platelet-derived growth factor receptor". Exp Cell Res. 279 (1): 21–33. doi:10.1006/excr.2002.5576. PMID 12213210.
  6. ^ Kato M, Miki H, Kurita S, Endo T, Nakagawa H, Miyamoto S, Takenawa T (Feb 2002). "WICH, a novel verprolin homology domain-containing protein that functions cooperatively with N-WASP in actin-microspike formation". Biochem Biophys Res Commun. 291 (1): 41–7. doi:10.1006/bbrc.2002.6406. PMID 11829459.
  7. ^ a b "Entrez Gene: WIPF2 WAS/WASL interacting protein family, member 2".

Further reading

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