WBP1

WBP1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1JMQ, 1K5R
Identifiers
Aliases	WBP1, WBP-1, WW domain binding protein 1
External IDs	OMIM: 606961; MGI: 104710; HomoloGene: 8267; GeneCards: WBP1; OMA:WBP1 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	74,460,891 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	83,098,540 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; pituitary gland; ; amygdala; ; nucleus accumbens; ; anterior pituitary; ; putamen; ; caudate nucleus; ; right adrenal cortex; ; hippocampus proper; ; left lobe of thyroid gland;
	Top expressed in
	choroid plexus of fourth ventricle; ; external carotid artery; ; ventricular zone; ; internal carotid artery; ; vestibular sensory epithelium; ; ganglionic eminence; ; neural tube; ; medial ganglionic eminence; ; neural layer of retina; ; maxillary prominence;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; WW domain binding;
Cellular component	cellular component;
Biological process	biological process;
	Sources:Amigo / QuickGO
Orthologs
	23559
	22377
	ENSG00000239779
	ENSMUSG00000030035
	Q96G27
	P97764
	NM_012477
	NM_001083922; NM_001083923; NM_016757
	NP_036609
	NP_001077391; NP_001077392; NP_058037
	Wikidata
View/Edit Human	View/Edit Mouse

WW domain-binding protein 1 is a protein that in humans is encoded by the WBP1 gene.^[5]^[6]

The globular WW domain is composed of 38 to 40 semiconserved amino acids shared by proteins of diverse functions including structural, regulatory, and signaling proteins. The domain is involved in mediating protein-protein interactions through the binding of polyproline ligands.

This gene encodes a WW domain binding protein, which binds to the WW domain of Yes kinase-associated protein by a conserved region: XPPXY motif. The function of this protein has not been determined.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000239779 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000030035 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Chen HI, Sudol M (Sep 1995). "The WW domain of Yes-associated protein binds a proline-rich ligand that differs from the consensus established for Src homology 3-binding modules". Proc Natl Acad Sci U S A. 92 (17): 7819–23. Bibcode:1995PNAS...92.7819C. doi:10.1073/pnas.92.17.7819. PMC 41237. PMID 7644498.
^ ^a ^b "Entrez Gene: WBP1 WW domain binding protein 1".

Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ludes-Meyers JH, Kil H, Bednarek AK, et al. (2004). "WWOX binds the specific proline-rich ligand PPXY: identification of candidate interacting proteins". Oncogene. 23 (29): 5049–55. doi:10.1038/sj.onc.1207680. PMC 4143251. PMID 15064722.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Jolliffe CN, Harvey KF, Haines BP, et al. (2001). "Identification of multiple proteins expressed in murine embryos as binding partners for the WW domains of the ubiquitin-protein ligase Nedd4". Biochem. J. 351 Pt 3 (3): 557–65. doi:10.1042/0264-6021:3510557. PMC 1221394. PMID 11042109.
Chen HI, Einbond A, Kwak SJ, et al. (1997). "Characterization of the WW domain of human yes-associated protein and its polyproline-containing ligands". J. Biol. Chem. 272 (27): 17070–7. doi:10.1074/jbc.272.27.17070. PMID 9202023.
Pirozzi G, McConnell SJ, Uveges AJ, et al. (1997). "Identification of novel human WW domain-containing proteins by cloning of ligand targets". J. Biol. Chem. 272 (23): 14611–6. doi:10.1074/jbc.272.23.14611. PMID 9169421.

This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000239779 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000030035 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7644498-5] Chen HI, Sudol M (Sep 1995). "The WW domain of Yes-associated protein binds a proline-rich ligand that differs from the consensus established for Src homology 3-binding modules". Proc Natl Acad Sci U S A. 92 (17): 7819–23. Bibcode:1995PNAS...92.7819C. doi:10.1073/pnas.92.17.7819. PMC 41237. PMID 7644498.

[entrez-6] "Entrez Gene: WBP1 WW domain binding protein 1".

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References

Further reading