VAV2

VAV2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2DLZ, 2DM1, 2LNW, 2LNX, 4ROJ
Identifiers
Aliases	VAV2, VAV-2, vav guanine nucleotide exchange factor 2
External IDs	OMIM: 600428; MGI: 102718; HomoloGene: 2530; GeneCards: VAV2; OMA:VAV2 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	133,992,604 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	27,317,045 bp
RNA expression pattern
	Top expressed in
	parotid gland; ; ganglionic eminence; ; ventricular zone; ; body of pancreas; ; right lobe of liver; ; caput epididymis; ; right adrenal cortex; ; corpus epididymis; ; left adrenal cortex; ; jejunal mucosa;
	Top expressed in
	habenula; ; mesenteric lymph nodes; ; lumbar spinal ganglion; ; medullary collecting duct; ; seminal vesicula; ; cumulus cell; ; seminiferous tubule; ; conjunctival fornix; ; ganglionic eminence; ; molar;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	guanyl-nucleotide exchange factor activity; epidermal growth factor receptor binding; metal ion binding; protein binding; phosphotyrosine residue binding;
Cellular component	cytoplasm; cytosol; plasma membrane;
Biological process	regulation of cell size; intracellular signal transduction; Fc-gamma receptor signaling pathway involved in phagocytosis; regulation of GTPase activity; ephrin receptor signaling pathway; positive regulation of phosphatidylinositol 3-kinase activity; platelet activation; Fc-epsilon receptor signaling pathway; vascular endothelial growth factor receptor signaling pathway; cell projection assembly; angiogenesis; positive regulation of apoptotic process; regulation of Rho protein signal transduction; regulation of small GTPase mediated signal transduction; cell migration; signal transduction; lamellipodium assembly; small GTPase mediated signal transduction; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	7410
	22325
	ENSG00000160293
	ENSMUSG00000009621
	P52735
	Q60992
	NM_001134398; NM_003371
	NM_009500
	NP_001127870; NP_003362
	NP_033526
	Wikidata
View/Edit Human	View/Edit Mouse

Guanine nucleotide exchange factor VAV2 is a protein that in humans is encoded by the VAV2 gene.^[5]^[6]

VAV2 is the second member of the VAV oncogene family. Unlike VAV1, which is expressed exclusively in hematopoietic cells, VAV2 transcripts were found in most tissues.^[6]

Interactions

VAV2 is a GEF for RAC1, specifically in fibroblasts VAV2 is necessary for integrin, but not growth factor–dependent activation of RAC leading to lamellipodia formation.^[7] Double DH domain mutations, L342R/L343SVav2 function as a dominant negative, blocking VAV2 GEF activity for RAC1^[7] and a PH domain mutant is required for recruitment of VAV2 to the membrane in order to elicit GEF activity.^[7] VAV2 has also been shown to regulate collagen phagocytosis in a RAC1-dependent manner^[8] and interact with CD19^[9] and Grb2.^[10]^[11]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000160293 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000009621 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Henske EP, Short MP, Jozwiak S, Bovey CM, Ramlakhan S, Haines JL, Kwiatkowski DJ (June 1995). "Identification of VAV2 on 9q34 and its exclusion as the tuberous sclerosis gene TSC1". Ann Hum Genet. 59 (Pt 1): 25–37. doi:10.1111/j.1469-1809.1995.tb01603.x. PMID 7762982. S2CID 27548854.
^ ^a ^b "Entrez Gene: VAV2 vav 2 oncogene".
^ ^a ^b ^c Marignani PA, Kanai F (2001-07-09). "Vav2 is required for cell spreading". The Journal of Cell Biology. 154 (1): 177–186. doi:10.1083/jcb.200103134. ISSN 0021-9525. PMC 2196856. PMID 11448999.
^ Arora PD, Marignani PA, McCulloch CA (July 2008). "Collagen phagocytosis is regulated by the guanine nucleotide exchange factor Vav2". American Journal of Physiology. Cell Physiology. 295 (1): C130–C137. doi:10.1152/ajpcell.00168.2008. ISSN 0363-6143. PMC 2493554. PMID 18434624.
^ Doody GM, Billadeau D D, Clayton E, Hutchings A, Berland R, McAdam S, Leibson P J, Turner M (November 2000). "Vav-2 controls NFAT-dependent transcription in B- but not T-lymphocytes". EMBO J. 19 (22): 6173–84. doi:10.1093/emboj/19.22.6173. ISSN 0261-4189. PMC 305817. PMID 11080163.
^ Blagoev B, Kratchmarova Irina, Ong Shao-En, Nielsen Mogens, Foster Leonard J, Mann Matthias (March 2003). "A proteomics strategy to elucidate functional protein-protein interactions applied to EGF signaling". Nat. Biotechnol. 21 (3): 315–8. doi:10.1038/nbt790. ISSN 1087-0156. PMID 12577067. S2CID 26838266.
^ Bourguignon LY, Zhu H, Zhou B, Diedrich F, Singleton P A, Hung M C (Dec 2001). "Hyaluronan promotes CD44v3-Vav2 interaction with Grb2-p185(HER2) and induces Rac1 and Ras signaling during ovarian tumor cell migration and growth". J. Biol. Chem. 276 (52): 48679–92. doi:10.1074/jbc.M106759200. ISSN 0021-9258. PMID 11606575.

External links

Overview of all the structural information available in the PDB for UniProt: P52735 (Guanine nucleotide exchange factor VAV2) at the PDBe-KB.

This article on a gene on human chromosome 9 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000160293 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000009621 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7762982-5] Henske EP, Short MP, Jozwiak S, Bovey CM, Ramlakhan S, Haines JL, Kwiatkowski DJ (June 1995). "Identification of VAV2 on 9q34 and its exclusion as the tuberous sclerosis gene TSC1". Ann Hum Genet. 59 (Pt 1): 25–37. doi:10.1111/j.1469-1809.1995.tb01603.x. PMID 7762982. S2CID 27548854.

[entrez-6] "Entrez Gene: VAV2 vav 2 oncogene".

[:0-7] Marignani PA, Kanai F (2001-07-09). "Vav2 is required for cell spreading". The Journal of Cell Biology. 154 (1): 177–186. doi:10.1083/jcb.200103134. ISSN 0021-9525. PMC 2196856. PMID 11448999.

[8] Arora PD, Marignani PA, McCulloch CA (July 2008). "Collagen phagocytosis is regulated by the guanine nucleotide exchange factor Vav2". American Journal of Physiology. Cell Physiology. 295 (1): C130–C137. doi:10.1152/ajpcell.00168.2008. ISSN 0363-6143. PMC 2493554. PMID 18434624.

[pmid11080163-9] Doody GM, Billadeau D D, Clayton E, Hutchings A, Berland R, McAdam S, Leibson P J, Turner M (November 2000). "Vav-2 controls NFAT-dependent transcription in B- but not T-lymphocytes". EMBO J. 19 (22): 6173–84. doi:10.1093/emboj/19.22.6173. ISSN 0261-4189. PMC 305817. PMID 11080163.

[pmid12577067-10] Blagoev B, Kratchmarova Irina, Ong Shao-En, Nielsen Mogens, Foster Leonard J, Mann Matthias (March 2003). "A proteomics strategy to elucidate functional protein-protein interactions applied to EGF signaling". Nat. Biotechnol. 21 (3): 315–8. doi:10.1038/nbt790. ISSN 1087-0156. PMID 12577067. S2CID 26838266.

[pmid11606575-11] Bourguignon LY, Zhu H, Zhou B, Diedrich F, Singleton P A, Hung M C (Dec 2001). "Hyaluronan promotes CD44v3-Vav2 interaction with Grb2-p185(HER2) and induces Rac1 and Ras signaling during ovarian tumor cell migration and growth". J. Biol. Chem. 276 (52): 48679–92. doi:10.1074/jbc.M106759200. ISSN 0021-9258. PMID 11606575.

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Interactions

References

Further reading

External links