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B12 and Dorothy Hodgkin

In 1948, at a biochemical meeting in Oxford, Lester Smith, a researcher from Glaxo, brought his first crystals of vitamin B12. ^[1] Hodgkin created new crystals from some of his less useful crystals, and deduced the presence of a ring structure because the crystals were pleochroic, a finding which she later confirmed using X-ray crystallography.^[2] Scientists from Merck had previously crystallised B12, but had published only refractive indices of the substance. ^[3]

The final structure of Vitamin B12 was published in 1955. ^[4]

^ Hodgkin, Dorothy. "Beginning to work on vitamin B12". Web of Stories. Retrieved 14 October 2014.
^ Brink, C.; Hodgkin, D. C.; Lindsey, J.; Pickworth, J.; Robertson, J. H.; White, J. G. (1954). "Structure of Vitamin B12: X-ray Crystallographic Evidence on the Structure of Vitamin B12". Nature. 174 (4443): 1169–71. doi:10.1038/1741169a0. PMID 13223773.
^ RICKES, E. L.; BRINK, N. G.; KONIUSZY, F. R.; WOOD, T. R.; FOLKERS, K. (16 April 1948). "Crystalline Vitamin B12". Science. 107 (2781): 396–397. doi:10.1126/science.107.2781.396.
^ Hodgkin, D. C.; Pickworth, J.; Robertson, J. H.; Trueblood, K. N.; Prosen, R. J.; White, J. G. (1955). "Structure of Vitamin B12 : The Crystal Structure of the Hexacarboxylic Acid derived from B12 and the Molecular Structure of the Vitamin". Nature. 176 (4477): 325–8. doi:10.1038/176325a0. PMID 13253565.

[1] Hodgkin, Dorothy. "Beginning to work on vitamin B12". Web of Stories. Retrieved 14 October 2014.

[2] Brink, C.; Hodgkin, D. C.; Lindsey, J.; Pickworth, J.; Robertson, J. H.; White, J. G. (1954). "Structure of Vitamin B12: X-ray Crystallographic Evidence on the Structure of Vitamin B12". Nature. 174 (4443): 1169–71. doi:10.1038/1741169a0. PMID 13223773.

[3] RICKES, E. L.; BRINK, N. G.; KONIUSZY, F. R.; WOOD, T. R.; FOLKERS, K. (16 April 1948). "Crystalline Vitamin B12". Science. 107 (2781): 396–397. doi:10.1126/science.107.2781.396.

[4] Hodgkin, D. C.; Pickworth, J.; Robertson, J. H.; Trueblood, K. N.; Prosen, R. J.; White, J. G. (1955). "Structure of Vitamin B12 : The Crystal Structure of the Hexacarboxylic Acid derived from B12 and the Molecular Structure of the Vitamin". Nature. 176 (4477): 325–8. doi:10.1038/176325a0. PMID 13253565.

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