User:Greekgeekygirl/Abcodia
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| Company type | Private |
|---|---|
| Industry | Biotechnology |
| Founded | September 2010 |
Key people | CEO Dr Julie Barnes, COO Chris Hodkinson, Director of Science Dr Wendy Alderton Director of Business Development Dr Mike Fisher Chair Dr Andy Richards Non-Exec Director and Principle Investigator for UKCTOCS. Prof Ian Jacobs Non-Exec Directors Andrew Elder and Dr Claire Hooper |
| Website | http://www.abcodia.com |
Abcodia is a specialist company that focuses on biomarkers for cancer screening. Its aim is to discover and validate biomarkers that can be used for the early detection of cancer. Early detection provides more treatment options and has been shown to improve survival rates. Working in collaboration with academics, technology partners and commercial diagnostic partners, Abcodia aims to dramatically improve the way cancer is detected and managed.
History
[edit]Abcodia is a spin-out from University College London(UCL) and was founded in 2010. UCL granted Abcodia the exclusive commercialisation rights to a serum collection created by clinical scientists at the Institute for Women's Health at UCL. The serum biobank was formed as part of the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS)which was led by Professor Ian Jacobs and Professor Usha Menon. From 2001 to 2005, more than 202,000 women were randomly recruited onto the trial, all of whom provided a sample of blood on entry. Around 50,000 of these volunteers continued to provide samples annually until the end of 2011. All samples are stored in liquid nitrogen.
The biobank now contains more than 500,000 samples, 350,000 of which are longitudinal, i.e. they were taken from the same person over several years. The UCL team also created a valuable database of phenotypic, demographic and disease incidence for each volunteer. It shows that many volunteers who were originally healthy when they entered the trial have gone on to develop cancer or other debilitating disease.
Disease focus
[edit]Abcodia’s primary focus is the discovery and validation of biomarkers that will lead to the development of new biomarkers which will be clinically available for the early detection and screening of cancer around the world. In 2011 it made available serum from the biobank for pancreatic cancer and colorectal cancer for collaborative research, closely followed in 2012 by breast cancer and lung cancer.
Early detection and screening of cancer
[edit]Without better biomarkers that can accurately detect cancer at an early stage and can be used in national cancer screening programmes, cancer mortality will continue to rise. As the age of the population increases, incidence will also increase and early detection will become ever more important. world cancer factsheet show that by 2030 there will be 22 million people around the world diagnosed every year with cancer, an increase of 73% compared with 2008.
For some types of cancers, screening programmes are already in place (e.g. for cervical, colorectal and breast cancer). However, in some cases, current tests fall short of what is considered ideal by clinicians and in many other cancers, screening cannot be reliably performed.
External links
[edit]- [[Abcodia]]
- [UK Collaborative Trial of Ovarian Cancer Screening]
- World Cancer Factsheet published by the International Agency for Research on Cancer, World Health Organisation, Global Cancer Control and Cancer Research UK.
- Professor Ian Jacobs.
- Professor Usha Menon.
- Biomarkers.
References
[edit]1. Impact on mortality and cancer incidence rates of using random invitation from population registers for recruitment to trials. (Burnell et al).
2. Sensitivity and specificity of multimodal and ultrasound screening for ovarian cancer, and stage distribution of detected cancers: results of the prevalence screen of the UK Collaborative Trial of Ovarian Cancer Screening (Menon et al).
3. Sensitivity of transvaginal ultrasound screening for endometrial cancer in postmenopausal women: a case-control study within the UKCTOCS cohort. (Jacobs et al).
4. SEER Cancer Statistics Review, 1975-2009 (Vintage 2009 Populations), National Cancer Institute. (Howlader et al).
5. SEER Cancer Statistics Review, 1975-2009, for colorectal cancer.
Category:Biotechnology companies of the United Kingdom