Talk:Sphingosine

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Untitled

This section says that dehydrosphingosine (usually called 3-ketosphinganine) is enzymatically converted to sphingosine but it isn't. The carbonyl group is reduced, forming dihydrosphingosine (sphinganine), which reacts with a fatty acid-CoA, forming dihydroceramide, which is then dehydrogenated to form the trans double bond at carbons 4 and 5. This is ceramide, which can be hydrolyzed to liberate sphingosine and fatty acid.

Image Sphingosine synthesis corrected.png: Error

In the Biosynthesis section the image Sphingosine synthesis corrected.png depicts serine with an amine group on the secondary carbon and a hydroxyl group on a primary carbon. In the true structure of serine an hydroxyl group is on the secondary carbon and an amine group on the primary carbon.

The chemical structure of serine in File:Sphingosine synthesis corrected.png appears to be correct to me. It is incorrect to say that in serine a hydroxyl group is on the secondary carbon and an amine group is on the primary carbon - compare with the diagram in the article serine. -- Ed (Edgar181) 19:38, 10 August 2012 (UTC)[reply]

Biosynthesis

The Biosynthesis section needs citations from sources verifying the information. --Djinn32 (talk) 00:33, 4 October 2019 (UTC)[reply]