Talk:Pleckstrin homology domain

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Are you sure about "Pleckstrin homology domain (PH domain) is a protein region of approximately 120 amino acids that can bind Phosphatidylinositol lipids within biological membranes (such as Phosphatidylinositol (3,4,5)-trisphosphate and phosphatidylinositol (4,5)-bisphosphate), [...]"? I've looked this up in Alberts, Molecular Biology of the Cell, where it says (Fig. 15-58) that the IPs recognized by proteins with PH-domains are PI(3,4)P2 and PI(3,4,5)P3 and explicitely not PI(4,5)P2. -84.172.217.172 14:16, 11 February 2007 (UTC)[reply]

conserved Trypophane arguable

I work on a PH domain containing protein which does not contain a Tryptophane in the helical area. Perhaps its "structure inducing" (I miss a source for this statement) function is taken over by a phenylalanine I could locate but I think the text should be updated or deleted as this is a general overview on PH domains. --14:36, 12 July 2011 (UTC) — Preceding unsigned comment added by 132.187.29.93 (talk)