Talk:Dimethylethanolamine

Merge Dimethylethanolamine with DMAE:

• yes merge, clearly the chemicals are identical V8rik 22:32, 24 April 2006 (UTC)

Deanol is not only good for mood and concentation, it also reduce your blood pressure. Last not least it minimize the feeling for hunger, so it is good to lose your weight, if you want this. --Fackel 20:00, 30 May 2006 (UTC)

"It is believed that Dimethylaminoethanol is methylated to choline in the brain. It is known that Dimethylaminoethanol is processed by the liver into choline; however, the choline molecule charged and cannot pass the blood-brain barrier."

I don't want to edit this page since I know nothing about DMAE, but there's a word missing here: the choline molecule IS charged?Conservatif 15:06, 16 August 2006 (UTC)

Fixed. --Ed (Edgar181) 15:30, 16 August 2006 (UTC)

Uses

Interactions with Anesthetics

Discusses face creams only.

Effects On Skin

• what is the natural source of DMAE?
• what are its traditional uses if any?
• why is it in skin care products like the Skin Eternal range from Source Naturals?

Ceirius 07:28, 24 August 2006 (UTC)

I have not verified this info. but you may find answers here http://calorielab.com/news/2011/02/08/dmae/24.0.133.234 (talk) 10:33, 3 November 2013 (UTC)

"pathological reaction in skin cells" is caused by DMAE (2-dimethylaminoethanol)[1] Brian Pearson 00:46, 12 April 2007 (UTC)

• Trying to help pull together some content related to the skin... The question, I guess, is basically "Why is this stuff in skin care products?" If someone could put the answer in the article itself using some of this text and these cites as a springboard that would be cool :-)
  • Brian Pearson's link just above seems relevant (Anti-wrinkle compound causes pathological reaction in skin cells). If I'm reading it correctly it argues that DMEA damages skin cells which swell up in response, thereby make the skin less wrinkly (presumably until the swelling wears off?). Here's a bit from that article: "In vitro tests conducted by Dr. Marceau’s team revealed that the application of DMAE induces a quick and spectacular swelling of skin cell vacuoles called fibroblasts, which act as reservoirs and interface between the inside and the outside of the cell. In the hours following the application of DMAE, the researchers observed an important slowing down of cell division—sometimes coming to a complete stop, the inhibition of certain metabolic reactions, and the death of a significant percentage of fibroblasts. The mortality rate of fibroblasts, which varied according to DMAE concentration, was above 25% after 24 hours in the case of a concentration similar to the one resulting from normal use of an antiwrinkle cream. The thickening of the skin induced by the pathological swelling of the fibroblasts would explain the antiwrinkle effect of DMAE, according to the researchers."
  • It doesn't even appear to me that this basic mechanism wasn't already somewhat obvious back when European Patent EP0533126 was filed in 1992 with less clear language giving roughly the same idea about "damage and response"... Although in this case maybe it's an attempt to claim that "old" fibroblasts are dying and then "young" fibroblasts are stimulated to grow in their place? Here's some text from the patent: "Recent researches proved that treating the skin with fractions of pulmonary surfactant containing phospholipid mixtures the following phenomenon occurs: the fractions interpenetrate with the membranes of the cells which are present in the derm and analogously to what determined in the pulmonary alveolus, activate the macrophages, which, in this case, phagocytize and destroy the old fibroblasts. Accordingly, young fibroblasts proliferate, and subsequently produce the precursors of the typical elements of the derm in great quantity; collagen fibers, elastic fibers, proteoglycanes, fibronectin, etc. During a study for the identification of pulmonary surfactant fractions, it has been found that 1,2-dipalmitoyl-L-α-phosphatidyl-N,N-dimethylethanolamine surprisingly stimulates the cutaneous macrophages, thus contributing to the antiageing activity."
  • I'm not an expert in this field but if I was trying to boil this down it looks to me, roughly, like DMAE causes short term damage to elements in the skin by futzing with the cell membranes and then the physiological response and/or healing process has the effect of making wrinkles dissappear... more or less?
  • This seems like it would be in contrast to something like retinol (chemically very similar to the drug Tretinoin and Vitamin A) which is an actual nutrient/vitamin that helps regulate gene expression, seems to boost collagen production, leads to dry flaky skin when you have a dietary deficiency, and has metabolic associations with other big name chemicals like beta-carotene (basically beta carotene is two retinol molecules glued to each other) and rhodopsin (which detects light in the retina and has a component in the retinoid family of chemicals).

Is there any work done on how this helps Dislexciea? Or if it even helps at all?

This article needs info. about use in skin cream and if it is passed transdermally into the body.24.0.133.234 (talk) 10:38, 3 November 2013 (UTC)

The choline molecule

It is known that dimethylaminoethanol is processed by the liver into choline; however, the choline molecule is charged and cannot pass the blood-brain barrier.

Can we have a source on this? I don't know much about the subject, but this seems to be in disagreement with various sites on the Internet that say DMAE or centrophenoxine may be taken to increase levels of choline in the brain. René van Buuren (talk) 00:45, 20 July 2008 (UTC)

I can't remember the title of the paper anymore, but all those claims stem from one team's misinterpretated study aeons ago. Typical. 84.203.39.16 (talk) 21:57, 3 September 2009 (UTC)

According to the choline wiki, "The compound's polar groups, the quaternary amine and hydroxyl, render it lipid-insoluble, which might suggest it would be unable to cross the blood–brain barrier. However, a choline transporter that allows transport of choline across the blood–brain barrier exists.[45]"

Drilling through a few cites yields:

Acta Ophthalmol (Copenh). 1984 Oct;62(5):763-6.

Choline transport through the blood-retinal and the blood-brain barrier in vivo.

Karlsson C, Mäepea O, Alm A.

Abstract

The uptake index method was used to study retinal and cerebral uptake of [14H]labelled choline in rats. In both tissues a saturable uptake was observed. This uptake was significantly inhibited by 10-20 mM unlabelled choline chloride as well as by 10 mM hemicholinium-3. It is concluded that choline passes the blood-retinal barrier by a carrier-mediated transport system similar to that in the blood-brain barrier.

184.21.23.186 (talk) 04:47, 16 March 2013 (UTC)Lewis R. Goudy

Can you source where dmae extended lifespan? I am having trouble locating it online. —Preceding unsigned comment added by 62.215.150.141 (talk) 00:48, 31 December 2009 (UTC)