Talk:Abrin

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Intra-Wiki Disagreement

The first line of "use" is "Abrin is not known to have been weaponised", but the article on the plant has an entire section on it's use as a weapon, seemingly effectively. I'm not sure if I should just remove that entire section? It has cited sources, but so does.... http://en.wiki.x.io/wiki/Abrus_precatorius#As_a_weapon — Preceding unsigned comment added by 129.222.138.117 (talk) 18:01, 10 November 2022 (UTC)[reply]

Inconsistent data

This data point seems inconsistent with other data in the article:

"The estimated LD50 for humans is estimated to be 1 ng per kilogram of body weight, and it is considered to be extremely toxic."

Was that "ng" meant to refer to nanograms? If so, it contradicts the information in the head, which uses measures in micrograms and milligrams per kilogram. Nothing in the head comes anywhere close to the toxicity of one nanogram/kg for any method of introduction into the body. So, what was intended here? zadignose (talk) 10:26, 29 July 2013 (UTC)[reply]

External links modified

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Inaccurate interpretation of references

The second sentence in the article inaccurately reflects the information in the provided reference (Gill, DM. 1982). The sentence reads; "It [abrin] has a median toxic dose of 0.7 micrograms per kilogram of body mass when given to mice intravenously (approximately 31.4 times more toxic than ricin, being 22 micrograms per kilogram).[1]" Issues: 1) Toxicity values for abrin and ricin in Table 1 of Gill are represented as "minimum lethal dose" as indicated in footnote "a" not as "median toxic dose" as indicated in the article. 2) The i.v. mouse toxic dose for abrin in Gill is 700 ng/kg and 2.7 micrograms/kg for ricin, making abrin 3.8 times more toxic, not 31.4 times as stated in the Wiki article. The value "22 micrograms per kilogram" for ricin toxicity does not appear in Gill.

The third sentence in the article inaccurately reflects the information in the provided reference (Johnson et al.2009). The sentence reads; "The median toxic dose for humans ranges from 10 to 1000 micrograms per kilogram when ingested and is 3.3 micrograms per kilogram when inhaled.[2]" This sentence implies that the human inhalation lethal dose is 3.3 micrograms/kg, but the reference provides LD50 data for rats. There are no human toxicity data for any route of intoxication other than ingestion (usually of seeds). Furthermore, Johnson et al. provided a rat inhalation LD50 value of 3.7 micrograms/kg, making abrin and ricin essentially identical in potency via the inhalation route in rats.73.134.200.249 (talk) 03:05, 26 September 2017 (UTC)[reply]

Thanks for taking a closer look at the article. Would you like to make the changes you suggest? If you are not familiar with the Wiki Markup, it shouldn't be a problem in this instance, and I and others will see your edit and correct any markup problems. You can also refer to this page for editing help.--Quisqualis (talk) 03:37, 26 September 2017 (UTC)[reply]