Talk:2,4-Dinitrophenol

lethal dose

"Case reports have shown that an acute administration of 20–50 mg/kg in humans can be lethal." From personal experience I can tell you that 1000 mg for a 100kg male is very close to the lethal dosage. It induced a very high respiratory rate, high cardiac rate (over 180 bpm) & heat production that required the consumption of about 1 liter of water every 20 minutes while controlling body temperature by opening all windows in minus 10C temperature, laying directly on a water bed with a fan directed directly towards me at high speed. I did this experiment in trying to reach side effects levels. However, they are not linear with dosage.

"The inefficiency is proportional to the dose of DNP that is taken."

suggested edit "but the raise in body temperature follows an exponential curve as the body's heat evacuation strategies are overwhelmed."

This is obvious in retrospect. Heat production in proportional but body temperature depends on the evacuation of heat generated. This is what makes the use of this product very dangerous. An individual might get little response with regards to body temperature at a dose of 500mg. Doubling the dose might seem safe since body temperature remains unchanged at 500mg. This very close range between effective and nearly lethal makes the product dangerous. The accumulation effect is similar. The day following ingestion some of the DNP is not metabolized. If one chooses to take the product every day rather than every 2nd day then there is a buildup in the body. Boileaupa (talk) 17:32, 30 January 2015 (UTC)

Everything in WP needs to be based on reliable sources. Please see WP:VERIFY. It cannot be based on anyone's personal experience - please see WP:OR. For health related content, reliable sources are described in WP:MEDRS. Jytdog (talk) 17:35, 30 January 2015 (UTC)

"The lowest published lethal human oral dose of DNP is 4.3 mg/kg"2,4-Dinitrophenol (DNP): A Weight Loss Agent with Significant Acute Toxicity and Risk of Death, however "In studies of intermediate-duration oral exposure to 2,4-DNP, cases of death from agranulocytosis (described in the discussion of Hematological Effects) have been attributed to 2,4-DNP. These cases occurred during the usual dosing regimens for weight loss, employing increasing doses in one case from 2.9 to 4.3 mg/kg/day of 2,4-DNP for 6 weeks (Dameshek and Gargill 1934); a dose of 1.03 mg/kg/day 2,4-DNP for 46 days in another case (Goldman and Haber 1936); and in another, from 0.62 to 3.8 mg/kg/day 2,4-DNP as sodium 2,4-DNP for 41 days (Silver 1934)."ATSDR Dinitrophenols Health EffectsVaioG (talk) 12:11, 8 June 2018 (UTC)

Details of deaths

There appears to be some disagreement about how to cover the deaths as a result of consuming 2,4-DNP. I side with the current version which doesn't include specific cases as I think this is unnecessary and leads to WP:RECENTISM whenever any death is reported in the media. Can we discuss this before any more reverts are made? SmartSE (talk) 09:54, 23 April 2015 (UTC)

We should really get rid of the media articles and use this source instead. SmartSE (talk) 09:59, 23 April 2015 (UTC)

We do at least need redundant information on the doses that led to the deaths, unreliable as the victim's declarations may be. --IO Device (talk) 15:42, 23 April 2015 (UTC)

I agree, but not from newspapers. See this from the source I linked to above. SmartSE (talk) 10:55, 24 April 2015 (UTC)

Another trusted source covering the DNP deaths echa.europa.eu 2,4-Dinitrophenol CLH reportVaioG (talk) 12:17, 8 June 2018 (UTC)

Picture needed?

Curious if the article would benefit from a graphic depicting the substance in its distinctive yellow. Are there any fair-use pictures hiding out there on the internet? — Asgardiator ^{Iä! Iä!} 06:33, 15 September 2015 (UTC)

I've been looking for a few days, with little luck. Just photos with unknown authors, that have been published on various websites which we of course can't use. MutchyMan112 (talk) 19:29, 7 August 2018 (UTC)