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SERPINB10

From Wikipedia, the free encyclopedia
SERPINB10
Identifiers
AliasesSERPINB10, PI-10, PI10, serpin family B member 10
External IDsOMIM: 602058; MGI: 2138648; HomoloGene: 68430; GeneCards: SERPINB10; OMA:SERPINB10 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005024

NM_001160307
NM_198028

RefSeq (protein)

NP_005015

NP_001153779
NP_932145

Location (UCSC)Chr 18: 63.9 – 63.94 MbChr 1: 107.46 – 107.48 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Serpin peptidase inhibitor, clade B (ovalbumin), member 10 is a protein that in humans is encoded by the SERPINB10 gene.[5]

Function

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The superfamily of high molecular weight serine proteinase inhibitors (serpins) regulate a diverse set of intracellular and extracellular processes such as complement activation, fibrinolysis, coagulation, cellular differentiation, tumor suppression, apoptosis, and cell migration. Serpins are characterized by a well-conserved tertiary structure that consists of 3 beta sheets and 8 or 9 alpha helices.[6] A critical portion of the molecule, the reactive center loop connects beta sheets A and C. Protease inhibitor-10 (PI10; SERPINB10) is a member of the ov-serpin subfamily, which, relative to the archetypal serpin PI1, is characterized by a high degree of homology to chicken ovalbumin, lack of N- and C-terminal extensions, absence of a signal peptide, and a serine rather than an asparagine residue at the penultimate position.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000242550Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000092572Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Serpin peptidase inhibitor, clade B (ovalbumin), member 10".
  6. ^ Huber R, Carrell RW (November 1989). "Implications of the three-dimensional structure of alpha 1-antitrypsin for structure and function of serpins". Biochemistry. 28 (23): 8951–66. doi:10.1021/bi00449a001. PMID 2690952.
  7. ^ * Bartuski AJ, Kamachi Y, Schick C, Overhauser J, Silverman GA (August 1997). "Cytoplasmic antiproteinase 2 (PI8) and bomapin (PI10) map to the serpin cluster at 18q21.3". Genomics. 43 (3): 321–8. doi:10.1006/geno.1997.4827. PMID 9268635.

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.