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RNF7

From Wikipedia, the free encyclopedia

RNF7
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesRNF7, CKBBP1, ROC2, SAG, ring finger protein 7, rbx2
External IDsOMIM: 603863; MGI: 1337096; HomoloGene: 84476; GeneCards: RNF7; OMA:RNF7 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001201370
NM_014245
NM_183063
NM_183237

NM_011279
NM_001311135

RefSeq (protein)

NP_001188299
NP_055060
NP_899060

NP_001298064
NP_035409

Location (UCSC)Chr 3: 141.74 – 141.75 MbChr 9: 96.35 – 96.36 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

RING-box protein 2 is a protein that in humans is encoded by the RNF7 gene.[5][6][7]

The protein encoded by this gene is a highly conserved ring finger protein. It is an essential subunit of SKP1-cullin/CDC53-F box protein ubiquitin ligases, which are a part of the protein degradation machinery important for cell cycle progression and signal transduction. This protein interacts with, and is a substrate of, casein kinase II (CSNK2A1/CKII). The phosphorylation of this protein by CSNK2A1 has been shown to promote the degradation of IkappaBalpha (CHUK/IKK-alpha/IKBKA) and p27Kip1(CDKN1B). Alternatively spliced transcript variants encoding distinct isoforms have been reported.[7]

Interactions

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RNF7 has been shown to interact with CSNK2B.[8]

See also

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References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000114125Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000051234Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Duan H, Wang Y, Aviram M, Swaroop M, Loo JA, Bian J, Tian Y, Mueller T, Bisgaier CL, Sun Y (April 1999). "SAG, a novel zinc RING finger protein that protects cells from apoptosis induced by redox agents". Mol Cell Biol. 19 (4): 3145–55. doi:10.1128/MCB.19.4.3145. PMC 84108. PMID 10082581.
  6. ^ Ohta T, Michel JJ, Schottelius AJ, Xiong Y (May 1999). "ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity". Mol Cell. 3 (4): 535–41. doi:10.1016/S1097-2765(00)80482-7. PMID 10230407. S2CID 19371828.
  7. ^ a b "Entrez Gene: RNF7 ring finger protein 7".
  8. ^ Ahn BH, Kim T H, Bae Y S (October 2001). "Mapping of the interaction domain of the protein kinase CKII beta subunit with target proteins". Mol. Cells. 12 (2). Korea (South): 158–63. doi:10.1016/S1016-8478(23)17077-4. ISSN 1016-8478. PMID 11710515.

Further reading

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