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Pam Sykes

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Pamela Sykes is an Australian medical scientist,[1] Emeritus Professor at the College of Medicine and Public Health and was the Chair of the Institutional Biosafety Committee at the Flinders Centre for Innovation in Cancer[2] at Flinders University. She is a Strategic Professor in the area of Preventive Cancer Biology and leads a research group which studies the biological effects of low-dose radiation.[3] She is a deputy presiding member of the Radiation Protection Committee of the Environmental Protection Authority (EPA) for the Government of South Australia[4] which advises the Minister of South Australia and the EPA on 'radiation protection in medical, industrial, scientific and public uses of ionising and non-ionising radiation'.[5] Her research has been published in National Library of Medicine (NIH),[6][7] Research Gate,[8][9] Epigenetics, Transgenic Research, Cell Biology and Toxicology, PLOS ONE, Mutation Research and the Journal of Clinical Pathology. She is an Associate Editor for the journal Radiation Research.[10] Sykes' research into the effects of low-dose ionising radiation has been funded by the United States Department of Energy's Low Dose Radiation Research Program since the early 2000s.[11][12] She also investigated how parthenolide could aid radiotherapy.[13]

As of 2016, Sykes is a member of the UCL Australia Nuclear Working Group.[14][15]

Selected Publications

[edit]
  • Until There Is a Resolution of the Pro-LNT/Anti-LNT Debate, We Should Head Toward a More Sensible Graded Approach for Protection From Low-Dose Ionizing Radiation, 2020.[16]
  • The combination of metformin and valproic acid has a greater anti-tumoral effect on prostate cancer growth in vivo than either drug alone, Flinders University, 2019.
  • Chronic low dose ethanol induces an aggressive metastatic phenotype in TRAMP mice, which is counteracted by parthenolide, 2018.[17]
  • MP83-08 combination of metformin and sodium valproate for prostate cancer: a rapid approach from bench to clinical trial, 2017.[18]

References

[edit]
  1. ^ "Emeritus Professor Pam Sykes". Flinders University. Retrieved 19 February 2025.
  2. ^ "Professor Pamela Sykes at Adelaide's Flinders University a long-time authority on the effects of low-dose radiation". Adelaide AZ. Retrieved 19 February 2025.
  3. ^ Desk, News (14 July 2011). "Radiation response a meltdown in reason". News. Retrieved 19 February 2025. {{cite web}}: |last= has generic name (help)
  4. ^ "About Us". EPSA. Retrieved 19 February 2025.
  5. ^ "EPA - Radiation Protection Authority". EPA. Retrieved 19 February 2025.
  6. ^ Martin, Olga A.; Sykes, Pamela J.; Lavin, Martin; Engels, Elette; Martin, Roger F. (1 August 2024). "What's Changed in 75 Years of RadRes? - An Australian Perspective on Selected Topics". Radiation Research. 202 (2): 309–327. doi:10.1667/RADE-24-00037.1. ISSN 1938-5404. PMID 38966925.
  7. ^ Marcu, Loredana G.; Bezak, Eva; Sykes, Pamela J. (1 August 2022). "Radiation Research Journals Need to Stipulate Minimal Dosimetry Requirements for Publishing Research Using X-Radiation Exposures". Radiation Research. 198 (2): 204–206. doi:10.1667/RADE-22-00063.1. ISSN 1938-5404. PMID 35640161.
  8. ^ "Research Gate". Research Gate. Retrieved 19 February 2025.
  9. ^ "Research Gate". Research Gate. Retrieved 19 February 2025.
  10. ^ "Flinders University". www.flinders.edu.au. Retrieved 2 November 2016.
  11. ^ "Ignorance Drives Radiation Fears". fmcfoundation.com.au. Flinders Foundation. 5 June 2011. Retrieved 2 November 2016.
  12. ^ "Radiation response a meltdown in reason". blogs.flinders.edu.au. Flinders University. 14 July 2011. Retrieved 2 November 2016.
  13. ^ Toit, Carly du (13 September 2017). "Surprise discovery to help those with prostate cancer". ACRF. Retrieved 19 February 2025.
  14. ^ "Nuclear Working Group UCL Australia". UCL Australia. Retrieved 2 November 2016.
  15. ^ "Pam Sykes - UCL Australia". UCL Australia. Retrieved 2 November 2016.
  16. ^ Sykes, Pamela J. (1 April 2020). "Until There Is a Resolution of the Pro-LNT/Anti-LNT Debate, We Should Head Toward a More Sensible Graded Approach for Protection From Low-Dose Ionizing Radiation". Dose-Response. 18 (2): 155932582092165. doi:10.1177/1559325820921651. ISSN 1559-3258. PMC 7218310. PMID 32425725.
  17. ^ Morel, Katherine L.; Ormsby, Rebecca J.; Solly, Emma L.; Tran, Linh N. K.; Sweeney, Christopher J.; Klebe, Sonja; Cordes, Nils; Sykes, Pamela J. (1 October 2018). "Chronic low dose ethanol induces an aggressive metastatic phenotype in TRAMP mice, which is counteracted by parthenolide". Clinical & Experimental Metastasis. 35 (7): 649–661. doi:10.1007/s10585-018-9915-9. ISSN 1573-7276.
  18. ^ Tran, Linh N.K.; Kichenadasse, Ganessan; Ormsby, Rebecca J.; Morel, Katherine L.; Butler, Lisa M.; Centenera, Margaret M.; Sykes, Pamela J. (April 2017). "MP83-08 Combination of Metformin and Sodium Valproate for Prostate Cancer: A Rapid Approach From Bench to Clinical Trial". Journal of Urology. 197 (4S). doi:10.1016/j.juro.2017.02.2576. ISSN 0022-5347.
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