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PRSS2

From Wikipedia, the free encyclopedia
PRSS2
Identifiers
AliasesPRSS2, TRY2, TRY8, TRYP2, protease, serine 2, serine protease 2
External IDsOMIM: 601564; MGI: 102759; HomoloGene: 122141; GeneCards: PRSS2; OMA:PRSS2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001303414
NM_002770

NM_009430

RefSeq (protein)

NP_001290343
NP_002761

NP_033456

Location (UCSC)Chr 7: 142.76 – 142.77 MbChr 6: 41.5 – 41.5 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Protease, serine, 2 (trypsin 2) is a protein that in humans is encoded by the PRSS2 gene.[5]

Function

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This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is secreted by the pancreas and cleaved to its active form in the small intestine. It is active on peptide linkages involving the carboxyl group of lysine or arginine. This gene and several other trypsinogen genes are localized to the T cell receptor beta locus on chromosome 7. [provided by RefSeq, Jul 2008].

References

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  1. ^ a b c ENSG00000275896 GRCh38: Ensembl release 89: ENSG00000282049, ENSG00000275896Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000057163Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Protease, serine, 2 (trypsin 2)".

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.