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PLXNB2

From Wikipedia, the free encyclopedia
PLXNB2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPLXNB2, MM1, Nbla00445, PLEXB2, dJ402G11.3, plexin B2
External IDsOMIM: 604293; MGI: 2154239; HomoloGene: 66630; GeneCards: PLXNB2; OMA:PLXNB2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_012401

NM_001159521
NM_001284506
NM_138749

RefSeq (protein)

NP_001152993
NP_001271435
NP_620088

Location (UCSC)Chr 22: 50.27 – 50.31 MbChr 15: 89.04 – 89.06 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Plexin-B2 is a protein that in humans is encoded by the PLXNB2 gene.[5][6][7]

Function

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Members of the B class of plexins, such as PLXNB2 are transmembrane receptors that participate in axon guidance and cell migration in response to semaphorins (Perrot et al. (2002)).[supplied by OMIM][7]

Interactions

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PLXNB2 has been shown to interact with ARHGEF11.[6][8]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000196576Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000036606Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Tamagnone L, Artigiani S, Chen H, He Z, Ming GI, Song H, Chedotal A, Winberg ML, Goodman CS, Poo M, Tessier-Lavigne M, Comoglio PM (Oct 1999). "Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates". Cell. 99 (1): 71–80. doi:10.1016/S0092-8674(00)80063-X. PMID 10520995.
  6. ^ a b Perrot V, Vazquez-Prado J, Gutkind JS (Nov 2002). "Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia-associated Rho GEF (LARG) and PDZ-RhoGEF". J Biol Chem. 277 (45): 43115–20. doi:10.1074/jbc.M206005200. PMID 12183458.
  7. ^ a b "Entrez Gene: PLXNB2 plexin B2".
  8. ^ Swiercz JM, Kuner R, Behrens J, Offermanns S (Jul 2002). "Plexin-B1 directly interacts with PDZ-RhoGEF/LARG to regulate RhoA and growth cone morphology". Neuron. 35 (1): 51–63. doi:10.1016/S0896-6273(02)00750-X. PMID 12123608.

Further reading

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