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PLA2G1B

From Wikipedia, the free encyclopedia
PLA2G1B
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPLA2G1B, PLA2, PLA2A, PPLA2, phospholipase A2 group IB
External IDsOMIM: 172410; MGI: 101842; HomoloGene: 715; GeneCards: PLA2G1B; OMA:PLA2G1B - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000928

NM_011107
NM_001356586
NM_001356587

RefSeq (protein)

NP_000919

NP_035237
NP_001343515
NP_001343516

Location (UCSC)Chr 12: 120.32 – 120.33 MbChr 5: 115.6 – 115.61 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Phospholipase A2, group 1B is an enzyme that in humans is encoded by the PLA2G1B gene.[5][6]

Function

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Phospholipase A2 (EC 3.1.1.4) catalyzes the release of fatty acids from glycero-3-phosphocholines. The best known varieties are the digestive enzymes secreted as zymogens by the pancreas of mammals as well as fish.[7] Sequences of pancreatic PLA2 enzymes from a variety of mammals have been reported. One striking feature of these enzymes is their close homology to venom phospholipases of snakes. Other forms of PLA2 have been isolated from brain, liver, lung, spleen, intestine, macrophages, leukocytes, erythrocytes, inflammatory exudates, chondrocytes, and platelets.[6][8]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000170890Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029522Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Dennis EA (Jun 1994). "Diversity of group types, regulation, and function of phospholipase A2". J Biol Chem. 269 (18): 13057–60. doi:10.1016/S0021-9258(17)36794-7. PMID 8175726.
  6. ^ a b "Entrez Gene: PLA2G1B phospholipase A2, group IB (pancreas)".
  7. ^ Sæle O, Nordgreen A, Olsvik PA, Hamre K (2010). "Characterisation and expression of secretory phospholipase A2 group IB during ontogeny of Atlantic cod ( Gadus morhua)". Br J Nutr. 105 (2): 1–10. doi:10.1017/S0007114510003466. PMID 20836903.
  8. ^ Seilhamer JJ, Randall TL, Yamanaka M, Johnson LK (1987). "Pancreatic phospholipase A2: isolation of the human gene and cDNAs from porcine pancreas and human lung". DNA. 5 (6): 519–27. doi:10.1089/dna.1.1986.5.519. PMID 3028739.

Further reading

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