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ONECUT1

From Wikipedia, the free encyclopedia
ONECUT1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesONECUT1, HNF-6, HNF6, HNF6A, one cut homeobox 1
External IDsOMIM: 604164; MGI: 1196423; HomoloGene: 3309; GeneCards: ONECUT1; OMA:ONECUT1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004498

NM_008262

RefSeq (protein)

NP_004489

NP_032288

Location (UCSC)Chr 15: 52.76 – 52.79 MbChr 9: 74.77 – 74.8 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

One cut homeobox 1 is a protein that in humans is encoded by the ONECUT1 gene. [5]

Function

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This gene encodes a member of the Cut homeobox family of transcription factors. Expression of the encoded protein is enriched in the liver, where it stimulates transcription of liver-expressed genes, and antagonizes glucocorticoid-stimulated gene transcription. This gene may influence a variety of cellular processes including glucose metabolism, cell cycle regulation, and it may also be associated with cancer. Alternative splicing results in multiple transcript variants.

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000169856Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000043013Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: One cut homeobox 1". Retrieved 2016-04-13.

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.