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Non-coding RNA in the species Homo sapiens
MALAT1 (Metastasis Associated Lung Adenocarcinoma Transcript 1 ) also known as NEAT2 (Nuclear-Enriched Abundant Transcript 2 ) is an infrequently spliced long non-coding RNA , which is highly conserved amongst mammals and highly expressed in the nucleus .[ 3] expression of metastasis -associated genes .[ 4] cell motility via the transcriptional and/or post-transcriptional regulation of motility-related genes.[ 5] temperature-dependent sex determination in the Red-eared slider turtle (Trachemys scripta [ 6]
Expression in alcoholic brains [ edit ] Transcripts of MALAT1 are significantly increased in the cerebellum of human alcoholics, as well as in similar regions of rat brains after the withdrawal of ethanol vapours. This alcohol-induced upregulation of MALAT1 may be responsible for differential expression of a number of proteins which contribute to ethanol tolerance and dependency in humans.[ 7]
Prognostic potential in cancer [ edit ] Elevated MALAT1 expression is correlated with poor overall survival in various types of cancer, suggesting that this gene is a prognostic factor for different types of cancer.[ 8] [ 9]
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