Jin Kim Montclare
Jin Kim Montclare | |
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![]() Jin Kim Montclare in 2017 | |
Alma mater | Fordham University Yale University |
Known for | Biomolecular engineering |
Awards | AAAS Leshner Fellow (2019) Agnes Fay Morgan Research Award (2015) |
Scientific career | |
Institutions | California Institute of Technology New York University |
Thesis | Specific recognition of DNA by natural transcription factors and miniature protein mimics (2002) |
Jin Kim Montclare is a Professor of Chemical and Biomolecular Engineering at New York University. She creates novel proteins that can be used in drug delivery, tissue regeneration, and medical treatment. She is a 2019 AAAS Leshner Leadership Fellow and has been inducted into the AIMBE College of Fellows.
Early life and education
[edit]Montclare was born in The Bronx. She is a first-generation Korean American.[1] She became interested in chemistry in high school.[2] She studied at Fordham University, where she majored in chemistry and minored in philosophy.[3] She earned her bachelor's degree in 1997.[1] She was awarded the Merck Index Award for excellence in organic chemistry and the Clare Boothe Luce Scholarship for women in science. Montclare was elected a member of Iota Sigma Pi. She moved to Yale University for her graduate degree, earning a master's in 2001 and a PhD in 2003. She worked in the lab of Alanna Schepartz, completing a thesis on the recognition of DNA by natural transcription factors.[4] Her graduate research was supported by the National Science Foundation and Pfizer.[4] She attributes her passion for chemistry to her mentors, including her grandmother.
Research and career
[edit]Montclare joined California Institute of Technology as an National Institutes of Health postdoctoral fellow, where she began to work on engineering new molecules with David A. Tirrell.[5] She joined New York University in 2005, where she leads the Protein Engineering and Molecular Design Lab.[6][7]
Montclare has worked with the United States Department of Defense to detoxify organophosphates, which are commonly used in pesticides and as warfare agents.[8] She develops stable, activate fluorinated phosphotriesterase (PTE) variants by combining PTE with non-canonical amino acids.[9] She has also developed protein-engineered hydrogels that could be used as biomimetic materials.[10] Instead of synthetically creating polymers, Montclare uses biologically engineered proteins that can be easily controlled by external stimuli.[11] Montclare's protein-based hydrogels can be used to direct neuronal growth for brain augmentation.[12] The hydrogels could be used to heal wounds, sense or control the flow of fluids or deliver medicine.[11] They are made from Escherichia coli bacterium which are patterned onto substrates, similar to how geckos can adhere to surfaces.[11] The She has developed a range of other nanomaterials derived from proteins, including coiled-coil fibres and helix-elastin block polymers.[13][14]
Other research in the Montclare group includes the design of protein-lipid macromolecular systems that can be used to transport nanoparticles, drugs, and genes to treat a variety of medical conditions.[10] The lipoprotoeplexes can be used to deliver drugs and genes across many types of cells in a GeneTrain.[15] They can form complexes with nucleic acid and small hydrophobic drugs.[16][17] The lipid container permits transfection past a cell membrane, whilst the protein capsule can bind chemotherapeutic molecules.[18]
Public engagement and advocacy
[edit]Montclare has been involved with outreach programs to introduce people in K-12 Education to science studies at the NYU Tandon School of Engineering.[19] She hosts a group of high school students for research opportunities every summer as well as leading outreach programs in Brooklyn high schools.[8] Montclare is part of the National Science Foundation Innovation Corps (I-Corps) program, and since 2013 has directed the New York University Tandon I-Corps site, the Convergence of Innovation and Entrepreneurship (CIE) Institute.[20][21][22] At the CIE Montclare seeks to increase the representation of women and underrepresented minority entrepreneurs, with the hope to increase their participation in STEM careers.[20] Whilst only 20% of engineering students in the United States are women, at New York University women make up between 40 and 45%.[23] She has written for The Huffington Post about the need for parents and adults to be more proactive in engaging their children with science.[24] Montclare co-founded inSchoolApps, who make web-based applications for science-based applications.[23][25] Montclare was featured in the Marvel Comics Unstoppable Wasp.[26]
Awards and honours
[edit]- 2006 Othmer Institute Othmer Junior Fellow[citation needed]
- 2006 Wechsler Award for Excellence[27]
- 2007 Air Force Research Laboratory Young Investigator Award[28]
- 2010 New York University Jacobs Excellence in Education Award[29]
- 2014 Distinguished Award for Excellence, Dedication to Invention, Innovation and Entrepreneurship[30]
- 2014 Executive Leadership in Academic Technology and Engineering Fellowship[31]
- 2015 Agnes Fay Morgan Research Award[1]
- 2016 American Chemical Society Rising Star Award[19]
- 2019 AAAS Leshner Leadership Fellow[10][32]
- 2019 AIMBE College of Fellows[33]
Patents
[edit]- 2008 Polymer carrier[34]
- 2016 Protein engineered systems for delivery of molecules[35]
- 2016 Fluorinated protein-based polymeric carriers[36]
- 2017 Protein nanofibers from self-assembling pentamers[37]
- 2017 Engineered fluorinated biomaterials[38]
- 2017 Protein polymer gold nanoparticle hybrid materials for small molecule delivery[39]
- 2017 Phosphotriesterase enzymes, methods and compositions related thereto[40]
References
[edit]- ^ a b c "2015 Morgan Research Award" (PDF). Iota Sigma Pi. Retrieved 2019-02-17.
- ^ "Jin Montclare". STEM Women on Fire. Retrieved 2019-02-17.
- ^ "Career Advice From Jin Montclare, Biochemist". Career Girls. June 2015. Retrieved 2019-02-17.
- ^ a b "Schepartz Laboratory | Intranet". schepartzlab.yale.edu. Retrieved 2019-02-17.
- ^ "Speaker Bios – Nanoscience Initiative". Retrieved 2019-02-17.
- ^ "Jin Kim Montclare | NYU Tandon School of Engineering". engineering.nyu.edu. Retrieved 2019-02-17.
- ^ "Jin Montclare, NYU – Gene Therapy". academicminute.org. 17 November 2014. Retrieved 2019-02-17.
- ^ a b "NYU Tandon Professor Named a Rising Star of Chemical Engineering | NYU Tandon School of Engineering". engineering.nyu.edu. Retrieved 2019-02-17.
- ^ Montclare, Jin. "Computationally Designed Stable Artificial Phosphotriesterases for Detoxification of Organophosphorus Agents".
{{cite journal}}
: Cite journal requires|journal=
(help) - ^ a b c "NYU Tandon Professor Named to Elite" (PDF). NYU. Retrieved 2019-02-12.
- ^ a b c "Protein-engineered gels mimic body's own functions". Phys.org. Retrieved 2019-02-17.
- ^ "Research Projects". Tumblr. Retrieved 2019-02-17.
- ^ Dhabi, NYU Abu. "Speakers and Abstracts". New York University Abu Dhabi. Retrieved 2019-02-17.
- ^ "NYU Positions Itself as a Leader in Biomedical Engineering | NYU Tandon School of Engineering". engineering.nyu.edu. Retrieved 2019-02-17.
- ^ "NYU's Jin Kim Montclare develops dual-delivery system to potentially treat multi-drug resistant cancer cells". News-Medical.net. 2015-09-11. Retrieved 2019-02-17.
- ^ Hopkins, Author Mellissa (2017-09-18). "Women Behind Innovation: Jin Kim Montclare, PhD". Edison Awards News. Retrieved 2019-02-17.
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has generic name (help) - ^ Liu, Che Fu; et al. (2017-08-04). "Efficient Dual siRNA and Drug Delivery Using Engineered Lipoproteoplexes". Biomacromolecules. 18 (9): 2688–2698. doi:10.1021/acs.biomac.7b00203. ISSN 1525-7797. PMID 28686014.
- ^ "Biomaterial delivers both a powerful drug and gene silencers: New hybrid shows promise in dealing double blow to cancer cells by delivering both a chemotherapeutic agent and RNA interfering technology that silences drug resistance". ScienceDaily. Retrieved 2019-02-17.
- ^ a b Siu, Diamond Naga (23 March 2016). "Q&A: Tandon Professor a Rising Star in STEM | Washington Square News". Retrieved 2019-02-17.
- ^ a b "NYU Tandon & NSF launch experiment to attract women & minorities to STEM entrepreneurship". EurekAlert!. Retrieved 2019-02-17.
- ^ "Want to Start a Tech Business? With I-Corps, You Can | NYU Tandon School of Engineering". engineering.nyu.edu. Retrieved 2019-02-17.
- ^ Montclare, Jin. "I-Corps: Lewis Dots 2.0".
{{cite journal}}
: Cite journal requires|journal=
(help) - ^ a b "Professor Jin Montclare Has Long Championed Women in STEM | NYU Tandon School of Engineering". engineering.nyu.edu. Retrieved 2019-02-17.
- ^ Montclare, Jin Kim (2013-08-19). "Nurturing a STEM Sisterhood". HuffPost. Retrieved 2019-02-17.
- ^ Patton, Madeline (2017-10-26). "The power of good mentors". Community College Daily. Retrieved 2019-02-17.
- ^ "Unstoppable Wasp: Meeting of the Minds Pt. 2". Marvel Entertainment. Retrieved 2019-02-17.
- ^ "Professor Montclare Receives Wechsler Award for Excellence | NYU Tandon School of Engineering". engineering.nyu.edu. Retrieved 2019-02-17.
- ^ "Jin Kim Montclare Awarded Competitive Research Grant by Air Force | NYU Tandon School of Engineering". engineering.nyu.edu. Retrieved 2019-02-17.
- ^ "NYU Tandon Teaching Awards | NYU Tandon School of Engineering". engineering.nyu.edu. Retrieved 2019-02-17.
- ^ Kretzschmar, Ilona (2018-01-23). "Spring 2018 Seminar Series - 01/29/18 | The City College of New York". www.ccny.cuny.edu. Retrieved 2019-02-17.
- ^ Kretzschmar, Ilona (2018-01-23). "Spring 2018 Seminar Series - 01/29/18 | The City College of New York". www.ccny.cuny.edu. Retrieved 2019-02-17.
- ^ "Incoming AAAS Leshner Fellows Focus on Human Augmentation". American Association for the Advancement of Science. Retrieved 2019-02-17.
- ^ "NYU Tandon professor inducted into biomedical engineering elite". EurekAlert!. Retrieved 2019-03-27.
- ^ Polymer carrier, retrieved 2019-02-17
- ^ Protein engineered systems for delivery of molecules, retrieved 2019-02-17
- ^ Fluorinated protein-based polymeric carriers, retrieved 2019-02-17
- ^ Protein nanofibers from self-assembling pentamers, retrieved 2019-02-17
- ^ Engineered fluorinated biomaterials, retrieved 2019-02-17
- ^ Protein polymer gold nanoparticle hybrid materials for small molecule delivery, retrieved 2019-02-17
- ^ Phosphotriesterase enzymes, methods and compositions related thereto, retrieved 2019-02-17