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Integrin beta 8

From Wikipedia, the free encyclopedia
ITGB8
Identifiers
AliasesITGB8, integrin subunit beta 8
External IDsOMIM: 604160; MGI: 1338035; HomoloGene: 18567; GeneCards: ITGB8; OMA:ITGB8 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002214

NM_177290

RefSeq (protein)

NP_002205

NP_796264

Location (UCSC)Chr 7: 20.33 – 20.42 MbChr 12: 119.12 – 119.2 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Integrin beta-8 is a protein that in humans is encoded by the ITGB8 gene.[5]

Function

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This gene is a member of the integrin beta chain family and encodes a single-pass type I membrane protein with a VWFA domain and four cysteine-rich repeats. This protein noncovalently binds to an alpha subunit to form a heterodimeric integrin complex. In general, integrin complexes mediate cell-cell and cell-extracellular matrix interactions and this complex plays a role in human airway epithelial proliferation. Alternatively spliced variants which encode different protein isoforms have been described; however, not all the variants have been fully characterized.[5] Additionally, it has been shown to interact with RhoGDI1 to alter the activation of Rho GTPases to promote Glioblastoma cell invasiveness. Uncoupling the αvβ8-RhoGDI1 interaction has been seen to block GBM cell invasion by hyperactivating Rho GTPases.[6]

Clinical significance

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High expression levels of ITGB8 are associated with high angiogenic and poorly invasive glioblastoma tumors. Conversely low expression of ITGB8 correlates with highly invasive but low angiogenic tumors.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000105855Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025321Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: ITGB8 integrin, beta 8".
  6. ^ Reyes SB, Narayanan AS, Lee HS, Tchaicha JH, Aldape KD, Lang FF, Tolias KF, McCarty JH (January 2012). "αvβ8 Integrin Interacts with RhoGDI1 to Regulate Rac1 and Cdc42 Activation and Drive Glioblastoma Cell Invasion". Mol Biol Cell. 24 (4): 474–82. doi:10.1091/mbc.E12-07-0521. PMC 3571870. PMID 23283986.
  7. ^ Tchaicha JH, Reyes SB, Shin J, Hossain MG, Lang FF, McCarty JH (October 2011). "Glioblastoma Angiogenesis and Tumor Cell Invasiveness Are Differentially Regulated by {beta}8 Integrin". Cancer Res. 71 (20): 6371–81. doi:10.1158/0008-5472.CAN-11-0991. PMC 3193578. PMID 21859829.

Further reading

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