Jump to content

HIRIP3

From Wikipedia, the free encyclopedia
HIRIP3
Identifiers
AliasesHIRIP3, HIRA interacting protein 3
External IDsOMIM: 603365; MGI: 2142364; HomoloGene: 18218; GeneCards: HIRIP3; OMA:HIRIP3 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003609
NM_001197323

NM_172746

RefSeq (protein)

NP_001184252
NP_003600

NP_766334

Location (UCSC)Chr 16: 29.99 – 30 MbChr 7: 126.46 – 126.46 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

HIRA-interacting protein 3 is a protein that in humans is encoded by the HIRIP3 gene.[5][6]

The HIRA protein shares sequence similarity with Hir1p and Hir2p, the two corepressors of histone gene transcription characterized in the yeast, Saccharomyces cerevisiae. The structural features of the HIRA protein suggest that it may function as part of a protein complex. Recently, several cDNAs encoding HIRA-interacting proteins, or HIRIPs, have been identified. In vitro, the HIRIP3 gene product binds HIRA, as well as H2B and H3 core histones, indicating that a complex containing HIRA-HIRIP3 could function in some aspects of chromatin and histone metabolism.[6]

References

[edit]
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000149929Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000042606Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Lorain S, Quivy JP, Monier-Gavelle F, Scamps C, Lecluse Y, Almouzni G, Lipinski M (Sep 1998). "Core histones and HIRIP3, a novel histone-binding protein, directly interact with WD repeat protein HIRA". Mol Cell Biol. 18 (9): 5546–56. doi:10.1128/MCB.18.9.5546. PMC 109139. PMID 9710638.
  6. ^ a b "Entrez Gene: HIRIP3 HIRA interacting protein 3".

Further reading

[edit]